消瘀片对粥样硬化兔血浆ET和血清NO水平的影响  

Effects of Xiaoyu Tablets on the Levels of Plasma ET and Serum NO in Atherosclerotic Rabbits

作　　者：谢梅林[1] 顾振纶[2] 陈可冀[3] 周文轩 郭次仪 

机构地区：[1]上海中医药大学 [2]苏州中药研究所,苏州215007 [3]中国中医研究院 [4]香港保健协会

出　　处：《苏州医学院学报》2000年第3期201-202,208,共3页Acta Academiae Medicinae Suzhou

基　　金：香港保健协会资助

摘　　要：目的　探讨消瘀片抑制血管平滑肌细胞增生的可能作用机理。方法　采用高脂饮食加腹主动脉内膜剥脱术制成兔腹主动脉粥样硬化模型 ,通过放免法和比色法分别测定口服消瘀片 0 .16～ 0 .32 g/ (kg·d) 12周后血浆内皮素 (Endothelin - 1,ET - 1)和血清一氧化氮 (NitricOxide,NO)含量的消长变化。结果　服用消瘀片后的兔血浆ET - 1水平明显降低 ,而血清NO含量明显增加。结论　消瘀片可能是通过降低血浆ET - 1水平 ,增加血清NO含量而抑制动脉粥样硬化血管壁平滑肌细胞的增殖。Objective The experimental atherosclerotic rabbits were created by feeding high fat diet and by performing abrasion of the abdominal aorta endothelial cells.Method Changes in the levels of plasma endothelin (ET) and serum nitric oxide (NO) were measured by the radioimmunoassay and colorimetric method,respectively.Results The plasma ET was decreased and the serum NO was increased after being treated with xiaoyu tablet 0.16～0.32 g/kg·d -1 for 12 weeks in atherosclerotic rabbits.Conclution This might be one of action mechanism of xiaoyu tablets on inhibiting proliferation of SMC.

关 键 词：内皮素 一氧化氮 继样动脉硬化 中医药疗法 

分 类 号：R259.435[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]