广西叶下珠抗鸭乙型肝炎病毒的实验研究  

Experimental study on the effect of Guangxi phyllanthus urinaria on anti-duck hepatitis B virus

作　　者：陈压西[1] 郭树华[1] 齐珍元[1] 张定凤[1] 

机构地区：[1]重庆医科大学病毒性肝炎研究所,400010

出　　处：《重庆医科大学学报》2000年第1期39-40,共2页Journal of Chongqing Medical University

摘　　要：用重庆麻鸭乙型肝炎动物模型，观察广西叶下珠体内抗鸭乙型肝炎病毒（ＤＨＢＶ）的作用。用广西叶下珠治疗１月，检测用药前后血清中的ＤＨＢＶ ＤＮＡ及转氨酶、肝组织病理等。广西叶下珠用药２周、１月能使血清ＤＨＢＶ ＤＮＡ总体水平显著降低（Ｐ＜０．０５或Ｐ＜０．０１），且停药后ＤＮＡ滴度回升不明显。血清转氨酶检查及肝脏常规ＨＥ染色病理检查未发现叶下珠对肝脏有明显的毒性损害。广西叶下珠在体内有抗鸭乙型肝炎病毒的作用。The purpose of this work was to study the effect of Guangxi Phyllanthus urinaria on anti-duck hepatitis virus(DHBV) in vivo and provide an experimental basis for clinical treatment of patients with hepatitis B. The Chongqing duck hepatitis B virus model was treated with Phyllanthus urinaria once a day for a month at doses of 1g/kg、 5g/kg、10g/kg of body weight. DHBV DNA in serum was detected four times from the beginning to the end of the treatment, ALT and AST in serum were detected simultaneously. Phyllanthus urinaria could significantly lower the serum DHBV DNA level. After 1 week stopping treatment, serum DHBV DNA concentrations in Phyllanthus urinaria-treated ducks did not increase significamly. The study confirms the safety and potent antihepadnaviral activity of Phyllanthus urinaria in vivo.

关 键 词：广西叶下珠 鸭乙型肝炎病毒 动物模型 

分 类 号：R512.62[医药卫生—内科学]