氟西汀对右美沙芬代谢的抑制  

FLUOXETINE INHIBITION ON THE METABOLISM OF DEXTROMETHORPHAN

作　　者：陈冰[1] 蔡卫民[1] 

机构地区：[1]南京军区南京总医院临床药理科,南京210002

出　　处：《药学学报》2000年第3期177-180,共4页Acta Pharmaceutica Sinica

基　　金：国家人事部留学回国人员科技活动D类项目择优资助经费资助!(96HG0 1 )

摘　　要：目的 :研究氟西汀对右美沙芬 (DM )代谢的影响。方法 :19名健康受试者在连续服用 10d氟西汀前后 ,分别服用 2 0mgDM ,测定两次尿中DM及其代谢物右啡烷 (DX)浓度 ,计算代谢比值 (MR)和尿排百分率。结果 :19名受试者服用氟西汀后MR值明显提高 ,其中 8名极快代谢受试者 (VEM)MR值由 0 0 0 5± 0 0 0 4提高为 0 0 2 6±0 0 12 ,11名中速代谢受试者 (IM)MR值由 0 0 5± 0 0 4提高为 0 13± 0 0 6。受试者服用氟西汀前后尿排百分率以DM计分别为 1 0 %± 0 9%和 1 2 %± 0 9% ,以DX计分别为 4 0 %± 16%和 2 0 %± 14 %。结论AIM: To study the influence of fluoextine on the metabolism of dextromethorphan (DM) in 19 healthy Chinese subjects. METHODS: All subjects took 20 mg DM before and 10 days after fluoxetine therapy. The volume of 0～8 h urine was measured and the concentration of DM and its metabolite dextrophan (DX) in the urine were determined. Thereafter, the metabolic ratio (MR) of DM and the recovery of DM and DX in 0～8 h urine were calculated. RESULTS: The mean MRs at baseline and after fluoxetine therapy in 19 subjects were 0 03±0 04 and 0 09±0 07, respectively( P <0 01). Of these subjects, while the MRs for 8 very extensive metabolizers (VEMs) were 0 005±0 004 and 0 026±0 012( P <0 01), the MRs for 11 intermediate metabolizers (IMs) were 0 05±0 04 and 0 13±0 06 before and after fluoxetine therapy, respectively( P <0 01). However, no subject showed MR in the range of poor metabolizer (PM) after fluoxetine therapy. The 0～8 h recoveries of DM before and after fluoxetine were 1 0%±0 9% and 1 2%±0 9%( P >0 05) and the values of DX were 40%±16% and 20%±14%( P <0 01), respectively. CONCLUSION: This study suggests that fluoxetine significantly inhibit the metabolism of dextromethorphan in Chinese subjects.

关 键 词：氟西汀 右美沙芬 CYP2D6 代谢 

分 类 号：R971.43[医药卫生—药品] R969.1[医药卫生—药学]