缩宫素对大鼠背根神经节神经元胞体膜的作用  

Effect of oxytocin on the somatic membrane of rat DRG neurons

作　　者：司军强[1] 谢菁[1] 赵义梅[1] 张志琴[1] 奚剑辉 齐玲 徐辉 

机构地区：[1]石河子大学医学院临床医疗系生理学教研室,新疆832002

出　　处：《中国神经科学杂志》2000年第1期24-27,共4页

基　　金：国家自然科学基金!资助项目 ( 3 9860 0 2 7)

摘　　要：应用细胞内记录技术 ,观察了缩宫素 ( OXT,1 0 -8～ 1 0 -5mol/ L)对 2～ 3周龄大鼠背根神经节神经元的作用。在受检的 92个细胞中 ,有 71个神经元滴加缩宫素产生明显的超极化反应。在滴加 1 0 -5mol/ L缩宫素后 ,膜电导由平均的 3.68× 1 0 -7S增加约 2 1 .43%。灌流平衡液中的 Na Cl以氯化胆碱置代或用 Cd2 +阻断Ca2 +通道后 ,OXT引起超极化反应的幅值无明显变化。当灌流平衡液中含 1 0 -2 mol/ L四乙基碘化铵后 ,OXT引起的超极化反应幅值明显减小。The effection of oxytocin (10 -8 ～10 -5 mol/L) on dorsal root ganglion neurones was studied by intracellular recording in two to three week Wistar rats. In 77.17% of the bath cells application of oxytocin induced marked membrane potential hyperpolarization (71/92). The membrane conductance increased 21.43% in average from control value of 3.68×10 -7 S during oxytocin induced hyperpolarization ( n =7). Bath cell NaCl in balanced salt solution (BSS) was substituted with choline choride, or BSS containing 10 -4 mol/L CdCl 2 was used failed to change the amplitude of oxytocin induced hyperpolarization. When BSS containing 10 -2 mol/L TEA was used, oxytocin induced hyperlarization was reduced.

关 键 词：缩宫素 背根神经节 超极化 大鼠 胞体膜 

分 类 号：R338[医药卫生—人体生理学]