回顾性分析急性间质性肾炎的临床和病理特点  

Retrospective Analysis of the Clinical and Pathological Features of the Acute Interstitial Nephritis

作　　者：程虹[1] 王小琴[1] 金劲松[1] 石君华[1] 

机构地区：[1]湖北省中医院肾内科,武汉430000

出　　处：《医学研究杂志》2012年第10期135-137,共3页Journal of Medical Research

摘　　要：目的探讨急性间质性肾炎(AIN)的病因、临床表现及肾脏病理改变的特点。方法回顾性分析笔者医院2007年7月～2011年7月通过病理确诊为AIN的患者,分析其发病原因、临床表现、病理改变及激素治疗效果。结果发病原因中药物相关性为83.3%,其中致病药物主要有抗生素,感冒药,非甾体类抗炎药,或这些药物的联合使用,另还有化疗药物,某些中药。由感染及免疫引起的较少。经药物治疗后43.3%的患者肾功能恢复正常。17例接受血液透析的患者中14例已经脱离透析治疗。结论 AIN的致病因素多种,药物是其最常见的致病因素。临床表现多样没有特异性。应早期明确诊断,早期治疗可以改善该疾病的预后。Objective To investigate the cause of the acute interstitial nephritis and its characteristics of clinical manifestations and pathological changes. Methods Causes, clinical manifestations, pathological changes and hormone treatment effects of 60 patients diag- nosed as AIN from July 2007 to July 2011 in our hospital had been retrospective analyzed. Results Drug - related cause was 83.3%. Disease causing drugs included primarily antibiotics, cold medicines, non -steroidal anti -inflammatory drugs, joint use of these drugs, other chemotherapy drugs, and some traditional Chinese medicine. Cause related to infection and immunity was less. The renal function of 43.3% patients returned to normal after drug treatment. Fourteen cases of 17 patients had stopped receiving dialysis treatment. Conclu- sion AIN＇s risk factors were multiply, and medication is the most common risk factors. The various clinical manifestations were nonspe- cific. Early diagnosis and treatment could imorove the oro~＇nosis of the disease.

关 键 词：急性间质性肾炎 临床病理分析 

分 类 号：R692.33[医药卫生—泌尿科学]