盐酸青藤碱对乳腺癌MCF-7细胞增殖影响的初探  

Effect of sinomenine hydrochloride on cell proliferation of human breast cancer cell MCF-7

作　　者：吴镁春[1] 陈迪钊[1] 

机构地区：[1]怀化学院化学化工系,湖南怀化418008

出　　处：《中南药学》2012年第10期739-741,共3页Central South Pharmacy

基　　金：湖南省教育厅产学研合作示范基地资助项目(No:06jj50020)

摘　　要：目的研究盐酸青藤碱对体外培养乳腺癌MCF-7细胞增殖的作用。方法体外培养人乳腺癌MCF-7细胞,四甲基偶氮唑蓝(MTT)法测定盐酸青藤碱(SIN)、5-氟尿苷(5-FUR)、SIN+5-FUR对乳腺癌MCF-7细胞增殖的影响。结果 SIN对人乳腺癌MCF-7细胞有增殖抑制作用,且呈浓度依赖性。SIN、5-FUR、SIN+5-FUR对MCF-7细胞的抑制强弱为:SIN>SIN+5-FUR>5-FUR。结论 SIN具有抑制人乳腺癌MCF-7细胞增殖的作用,且抑制效果强于5-FUR及SIN+5-FUR。Objective To investigate the effect of sinomenine on the proliferation of human breast cancer cell MCF-7.Methods The proliferation of cells was detected by MTT.Results SIN,5-FUR,and SIN combining with 5-FUR inhibited the growth of human breast cancer cell MCF-7.The inhibition order was： SINSIN combining with 5-FUR5-FUR.Conclusion Sinomenine can inhibit the proliferation of human breast cancer cell.SIN alone has a better inhibition in breast cell growth than 5-FUR and SIN combining 5-FUR.

关 键 词：乳腺癌细胞 细胞增殖 盐酸青藤碱 

分 类 号：R965[医药卫生—药理学] R979.1[医药卫生—药学]