注射用氯诺昔康与甲磺酸罗哌卡因注射液的配伍相容性研究  

Stability and compatibility of lornoxicam with ropivacaine mesylate in 0.9% sodium chloride injection

作　　者：方宝霞[1] 陈富超[1] 于琳[1] 李鹏[1] 钱浓[2] 朱西京[2] 

机构地区：[1]湖北医药学院附属东风医院药学部,湖北十堰442008 [2]湖北医药学院药学院,学生湖北十堰442000

出　　处：《中南药学》2012年第10期749-752,共4页Central South Pharmacy

基　　金：十堰市科学技术研究与开发计划项目(编号:2010st45)

摘　　要：目的考察注射用氯诺昔康与甲磺酸罗哌卡因注射液在0.9%氯化钠注射液中的配伍稳定性。方法在室温条件下,采用高效液相色谱法测定配伍液48 h内氯诺昔康与甲磺酸罗哌卡因的含量变化,并观察配伍液的外观及pH值变化。结果配伍液48 h内氯诺昔康与甲磺酸罗哌卡因的含量不断下降,并且配伍液在2 h后出现沉淀。结论室温条件下,注射用氯诺昔康与甲磺酸罗哌卡因注射液在0.9%氯化钠注射液中不稳定,临床不宜配伍应用。Objective To investigate the stability and compatibility of lornoxicam with ropivacaine mesylate in 0.9% sodium chloride injection.Methods An HPLC method was used to study the change of content after combination of lornoxicam with ropivacaine mesylate in 0.9% sodium chloride injection under ambient temperature within 48 h,and the appearance was observed and its pH value was determined.Results The contents of lornoxicam and ropivacaine mesylate steadily declined with precipitation at 2 h.Conclusion Lornoxicam with ropivacaine mesylate in 0.9% sodium chloride injection at ambient temperature is not stable,so clinical application should be avoided.

关 键 词：氯诺昔康 罗哌卡因 高效液相色谱法 配伍相容性 

分 类 号：R965.3[医药卫生—药理学]