噻托溴铵粉雾剂在慢性阻塞性肺病中的应用效果观察  

Efficacy of tiotropium bromide powder on chronic obstructive pulmonary diseases

作　　者：何东阳[1] 

机构地区：[1]广东医学院附属西乡人民医院呼吸内科,广东深圳518000

出　　处：《海南医学院学报》2012年第11期1585-1587,共3页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(112210393)~~

摘　　要：目的:探讨噻托溴铵粉雾剂治疗慢性阻塞性肺疾病(COPD)的临床效果。方法:70例COPD患者随机分为观察组与对照组,每组35例,观察组给予噻托溴铵粉雾剂治疗,对照组给予口服氨茶碱治疗,对比两组临床表现、肺功能及转化生长因子β1(TGF-β1)情况。结果:观察组治疗后临床总改善率(80.0%)显著高于对照组(51.4%)(P<0.05);观察组治疗后FEV1、FVC均显著高于治疗前(P<0.05),且显著高于对照组(P<0.05),而对照组则未见显著变化(P>0.05);两组治疗前TGF-β1阳性率无显著差异(P>0.05),观察组治疗后(28.6%)显著低于治疗前(62.9%)(P<0.01),且显著低于对照组(54.3%)(P<0.05),对照组治疗前后无显著差异(P>0.05)。结论:噻托溴铵粉雾剂用于COPD的治疗,可有效缓解临床症状体征,改善肺功能,有效延缓气道重塑,且并未增加不良反应的发生率,安全可靠,值得推广。Objective： To explore the clinical efficacy of tiotropium bromide powder on chronic ob- structive pulmonary diseases （COPD）. Methods：A total of 70 patients with COPD were randomly divided into the observation group （n=35） and that of the control group （n=35）. Tiotropium bromide powder was given to patients in the observation group, while aminophylline was given to the control group, then the clinical symptoms and signs, lung function, TGF-131 of sputum, and the adverse reactions were ob- served and compared between the two groups. Results： Total clinical improvement rate in the observation group （80.0%） was significantly higher than that of the control group （51.4%）（ P〈0.05）; FEV1, FVC was significantly higher after treatment in the observation group （P〈0.05）, and they were significantly higher than that of the control group （P〈0.05） ; positive rate of sputum TGF-131 （28.6%） in the observa- tion group was significantly lower after treatment （62.9 %） （P〈0.01）, and it was also significantly lower than that of the control group（54.3%）（P〈0.05） ; there was no significantly difference in the adverse re- action between two groups（P〉0.05）. Oonclusions： Tiotropium bromide powder can effectively alleviate clinical signs and symptoms, improve lung function, effectively delay the airway remodeling, without in- creasing the incidence of adverse reactions.

关 键 词：噻托溴铵 慢性阻塞性肺疾病 临床效果 

分 类 号：R563[医药卫生—呼吸系统]