糖尿病对慢性肾脏病患者血清RBP4水平的影响和临床意义  

Retinol Binding Protein 4 in CKD Patients with or without Diabetes Mellitus

作　　者：谢玉婷[1] 汪年松[1] 王锋[1] 薛勤[1] 高许萍[1] 简桂花[1] 盛晓华[1] 崔勇平[1] 俞岗[1] 李军辉[1] 陈玉强[1] 王筱霞[1] 

机构地区：[1]上海交通大学附属第六人民医院肾脏内科,上海200233

出　　处：《中国中西医结合肾病杂志》2012年第10期869-872,共4页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：上海市国际科技合作基金资助项目(No.11410708500);上海市科委基金资助项目(No.114119a6100;11DZ1921904);上海市级医院新兴前沿技术攻关项目(No.SHDC12006101);上海市科委基础研究重大项目(No.11DJ1400101);上海市科委重大项目(No.11DZ1973103)

摘　　要：目的:探讨糖尿病对CKD患者血清RBP4水平的影响和临床意义。方法:选取212例CKD1～5期患者及健康体检者24例,采用ELISA方法检测血清RBP4及甲状腺转运蛋白(TTR)的水平。结果:糖尿病对CKD患者血清RBP4水平影响的研究结果显示:CKD合并糖尿病组以及CKD不伴糖尿病组间eGFR、RBP4、RBP4/TTR水平差异无统计学意义;根据eGFR对患者进行分层研究,发现各组内糖尿病组与非糖尿病组的RBP4水平差异无统计学意义(CKD1～4,P>0.05)。而随着eGFR的下降,无论在糖尿病或非糖尿病患者中RBP4水平均明显升高。结论:随着eGFR的下降血清RBP4逐步升高,而RBP4水平与糖尿病之间差异无统计学意义相关。Objective：The aim of this study was to explore the effect of diabetes mellitus on RBP4 levels in CKD patients. Methods ：We investigated serum levels of RBP4, transthyretin （TFR） in 212 patients with stage 1 ~ 5 of CKD and in 24 healthy controis. RBP4 and TrR levels were measured by a commercial competitive enzyme - linked immunosorbent assay kit. Results： The results showed that： by comparing the eGFR,RBP4,TYR and RBP4/TrR levels of diabetic and non -diabetic subjects, we were unable to detected any differences. And we stratified all subjects according to eGFR and treatments to evaluate the in？ uence of kidney func- tion on RBP4 serum levels. After stratification, no further differences in the RBPg serum concentration were detectable between dia- betic and non- diabetic subjects （CKD1 -4, CT, MHD and PD, P 〉 0.05 ）. However, a decline in eGFR was accompanied by a gradual elevation of RBP4 serum levels in both diabetic and non - diabetic subjects. In PD and MHD patients, serum RBP4 and RBP4/TTR levels were significantly higher ＇than conservative CKD patients and control groups. Conclusion：The present study clearly demonstrates that a reduction of glomerular ？ ltration rate was accompanied by a gradual elevation of RBP4 serum levels, whereas we found weak associations between RBP4 serum concentrations and diabetes mellitus.

关 键 词：慢性肾脏病 视黄醇结合蛋白4 甲状腺转运蛋白 糖尿病 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]