乙型肝炎病毒感染者血清HBV DNA水平与HDL-C的相关性  

Association between serum hepatitis B virus DNA level with high density lipoprotein cholesterol in patients with hepatitis B virus infection

作　　者：陈群蓉[1] 谢春英[2] 孙顺昌[2] 曹建华[2] 彭运生[2] 

机构地区：[1]深圳市宝安区人民医院输血科,广东深圳518101 [2]深圳市宝安区人民医院检验科,广东深圳518101

出　　处：《热带医学杂志》2012年第10期1202-1204,共3页Journal of Tropical Medicine

基　　金：深圳市宝安区科技计划项目(2010594)

摘　　要：目的分析乙型肝炎病毒(HBV)感染者血清HBV DNA和高密度脂蛋白胆固醇(HDL-C)水平,探讨血清HBV DNA拷贝数与HDL-C水平的相关性。方法收集116例HBV感染者血清,通过实时荧光定量PCR法测定血清HBV DNA拷贝数,通过选择性抑制均相测定法分析血清HDL-C值;计算HBVDNA拷贝数与HDL-C的相关系数,并对相关系数进行显著性检验。结果在乙型肝炎病毒感染者中,血清HBV DNA拷贝数对数均值为(4.18±1.77)/ml,分布范围为(1.38～7.85)/ml;血清HDL-C浓度均值为(1.30±0.29)mmol/L,分布范围为(0.66～2.01)mmol/L。血清HBVDNA拷贝数与HDL-C水平存在负相关(r=-0.5346,P=0.0023)。结论 HDL-C对乙型肝炎病毒的复制有抑制作用。Objective To analyze serum hepatitis B virus DNA copies and high density lipoprotein cholesterol levels in patients with hepatitis B virus infection,and explore the association between virus DNA copies and high density lipoprotein cholesterol levels. Methods Serum samples were collected from 116 patients with hepatitis B virus infection. Serum hepatitis B virus DNA copies were determined by real-time quantitative polymerase chain reaction. High density lipoprotein cholesterol levels were measured with selective inhibition enzymatic methods. Correlation coefficient between serum hepatitis B virus DNA copies and high density lipoprotein cholesterol levels was calculated. Result Serum hepatitis B virus DNA copies were inversely correlated with high density lipoprotein cholesterol levels （r=-0.5346,P=0.0023） for patients with hepatitis B virus infection. Conclusion High density lipoprotein cholesterol may inhibit hepatitis B virus replication.

关 键 词：乙型肝炎病毒 DNA拷贝数 高密度脂蛋白胆固醇 

分 类 号：R512.62[医药卫生—内科学]