韶关市1～5岁儿童乙型肝炎血清学调查结果分析  

Investigation on the serological analysis of children (1～5 years old) with hepatitis B in Shaoguan

作　　者：吴晓惠[1] 钟启丽 陈胜莲 李书剑[1] 

机构地区：[1]韶关市疾病预防控制中心,广东韶关512028 [2]韶关市妇幼保健院,广东韶关512026

出　　处：《热带医学杂志》2012年第10期1255-1257,共3页Journal of Tropical Medicine

基　　金：韶关市医药卫生科研计划项目(Y09037);韶关市科技计划(医学类)项目(韶科〈卫〉2009-49)

摘　　要：目的了解乙肝疫苗纳入免疫规划后,韶关市1～5岁儿童乙肝病毒携带率与乙肝免疫水平,评价现阶段儿童乙肝的预防控制效果。方法从全市10个县(市、区)中采取分层整群随机抽样方法,选取2008年在幼儿园(托儿所)1～5岁儿童作为调查对象,收集血清样本采用酶联免疫吸附试验(ELISA)检测乙肝表面抗原(HBsAg)和表面抗体(抗-HBs)。结果共采集1～5岁儿童血清1485份,HBsAg阳性率为0.88%,随年龄增长有增高的趋势,男性0.93%、女性0.82%,经检验两者间差异无统计学意义(χ2=0.0586,P>0.05),地区间最高的是南雄市(0.97%),最低的武江区(0.80%),经检验两者间差异无统计学意义(χ2=0.0808,P>0.05);抗-HBs阳性率为65.86%,随年龄增长有下降趋势,男性65.01%、女性66.80%,经检验两者间差异无统计学意义(χ2=1.5424,P>0.05),地区间最高的武江区(66.27%),最低的是乳源县(65.47%),经检验两者间差异无统计学意义(χ2=0.0688,P>0.05)。结论韶关市乙肝疫苗免疫规划实施后,5岁以下儿童HBsAg携带率明显降低,预防效果显著;抗-HBs阳性率偏低,加大新生儿乙肝疫苗接种剂量。Objective To evaluate the impact of hepatitis B vaccination program （Expanded Program of Immunization, EPI） and the carrier status of children in Shaoguan city of Guangdong province. Methods Stratified sampling method was used in this study. Serum from children （1～5 years old at the nursery school in 2008） of the Shaoguan city was collected and the levels of HBsAg and anti-HBs were measured. Results Serum from 1 485 children were analyzed. The positive rate of HBsAg was 0.88%, and the level of HBsAg was increased with age. The positive rate of HBsAg in male and female was 0.93% and 0.82%, respectively, and the difference was not significant （χ2=0.0586,P0.05）. The percentage of positive rate in Nanxiong （0.97%） was not significantly different from Wujiang （0.8%） （χ2=0.0808,P0.05）. The positive rate of anti-HBs was 65.86%, and the percentage was decreasing with age. The positive rate of anti-HBs in male （65.01%） was not significantly different from the female （66.80%）（χ2=1.5424,P0.05）. The percentage of positive rate of anti-HBs in Wujiang （66.27%） is similar to Ruyuan （65.47%）（χ2=0.0688,P0.05）. Conclusions After implementation of the hepatitis B immunization programming in Shaoguan, the HBsAg carrier status was reduced significantly for the children aged 1～5 years old. The positive rate of anti-HBs is low, and the immunizing dose for neonatal should be increased

关 键 词：儿童 病毒性乙型肝炎 血清学 乙肝表面抗原 乙肝表面抗体 

分 类 号：R512.62[医药卫生—内科学]