3例原发性肝脏类癌的临床与病理特点分析  

Clinical and pathological characteristics of primary hepatic carcinoid: A report of 3 cases

作　　者：袁静[1] 宋欣[1] 陈薇[1] 王海屹[2] 王湛博[1] 

机构地区：[1]解放军总医院病理科,北京100853 [2]解放军总医院放射科,北京100853

出　　处：《军医进修学院学报》2012年第11期1129-1131,共3页Academic Journal of Pla Postgraduate Medical School

基　　金：解放军总医院苗圃基金(10KMM36)

摘　　要：目的探讨原发性肝脏类癌(primary hepatic carcinoid,PHC)的临床病理学特点及预后。方法总结3例原发性肝脏类癌的临床表现、影像学表现、病理组织学观察、免疫组织化学染色检测及随访结果,并对相关文献进行复习。结果原发性肝脏类癌的临床症状包括右上腹不适或疼痛;影像学显示多囊性单发或多发性结节;大体检查肿瘤呈灰黄色,多囊性,境界清楚;组织学检查肿瘤细胞呈圆形或卵圆形,具有中等量嗜酸性胞浆,细胞核呈细颗粒状,可见小核仁;免疫组织化学染色显示肿瘤细胞表达突触素(synaptophysin,Syn),嗜铬素A(chromogranin A,CgA)等神经内分泌标记。结论原发性肝脏类癌是一种罕见的原发于肝脏的神经内分泌肿瘤,临床症状无特异性,病理组织学特点及Syn、CgA等神经内分泌标记阳性有助于诊断。Objective To study the clinical and pathological characteristics of primary hepatic carcinoid（PHC）.Methods Clinical and pathological manifestations,imaging and histopathological findings in 3 PHC patients were studied with immunohistochemical staining with the related literature reviewed.The patients were followed up.Results The clinical symptoms of PHC patients were right upper abdomen discomfort or pain.Imaging showed polycystic solitary or multiple nodules.Grossly,the tumor was greyyellow in color,polycystic and well-circumscribed.Histology showed that the tumor cells were round or oval in shape with visible eosinophilic cytoplasm.The fine granular nuclei with visible small nucleoli were observed.Immunohistochemical staining displayed that the tumor cells expressed synaptophysin（Syn）,chromogranin A（CgA）.Conclusion PHC is a rare neuroendocrine tumor originating in liver with no specific clinical symptom.Histopathological findings and positive neuroendocrine markers（Syn and CgA） contribute to its diagnosis.

关 键 词：肝脏肿瘤 类癌 神经内分泌肿瘤 

分 类 号：R725.52[医药卫生—儿科]