单味中药抗肝纤维化机制研究概述  

Mechanism research of single Chinese herb antifibrotic

作　　者：李川[1] 吕文良[1] 陈兰羽[1] 何立丽[1] 张莎莎[1] 

机构地区：[1]中国中医科学院广安门医院感染疾病科

出　　处：《环球中医药》2012年第10期789-792,共4页Global Traditional Chinese Medicine

摘　　要：肝纤维化是各种慢性肝病发展为肝硬化的必经阶段,有效地预防、逆转肝纤维化可以延缓或防止肝硬化发生,从而在很大程度上改善肝病患者的预后。目前研究表明莪术、三七、柴胡等中药具有很好的抗肝纤维化疗效,其机制主要以减少转化生长因子β1(TGFβ1)及血小板衍生因子(PDGF)的表达、抑制肝星状细胞(HSC)增殖和活化、诱导活化HSC凋亡、降低对基质金属蛋白酶(MMPs)的抑制、抑制细胞外基质(ECM)生成等方面为主。Hepatic fibrosis is a necessary process of different chronic liver diseases. Preventing and reversing hepatic fibrosis can delay or prevent cirrhosis, which greatly improve the prognosis of patients with liver disease. The present study showed that some traditional Chinese medicines has antifibrotic efficacy, such as Ezhu, Sanqi, Chaihu etc. The main mechanism include reducing the expression of TGFβ1 and PDGF, inhibiting HSC proliferation and activation, inducing the apoptosis of the activate HSC, reducing the inhibition of MMPs, inhibiting ECM generation and so on.

关 键 词：单味中药 肝纤维化 机制 

分 类 号：R285[医药卫生—中药学]