485例红花注射液不良反应/事件报告分析  

Analysis of 485 reports of ADR/ADE caused by Honghua injection

作　　者：王丽[1] 李强 李文武[1] 张惠霞[1] 刘超[1] 

机构地区：[1]河南省食品药品评价中心,河南郑州450004 [2]郑州市食品药品检验所,河南郑州450006

出　　处：《中国现代医生》2012年第29期65-66,69,共3页China Modern Doctor

摘　　要：目的通过分析红花注射液不良反应发生的一般规律和特点,为临床合理用药提供参考。方法采用回顾性研究方法,对河南药品不良反应监测中心数据库收集的2011年485例红花注射液不良反应报告进行统计和分析。结果 50岁以上的患者328例,占67.63%;药品不良反应发生时间在30 min以内的患者314例,占64.75%;超剂量用药104例,占21.44%;联合用药34例,占7.01%;不良反应主要表现为皮肤及其附件损害。结论应加强对红花注射液的监测,提高临床合理用药水平,减少不良反应的发生。Objective To study the general pattern and characteristics of adverse drug reactions induced by Honghua injec- tion to provide references for clinical rational use of drug. Methods A total of 485 ADR/ADE reports of Honghua injection collected by Henan center for ADR monitoring in 2011 were analyzed using retrospective study method. Results 328 cases of patients over the age of 50 accounted for 67.63%; 314 cases of patients with ADR/ADE occurred within 30 minutes ac- counted for 64.75%; 104 cases of drug overdose accounted for 21.44%; 34 cases of combination therapy accounted for 7.01%; ADR/ADE mainly were lesion of skin and its appendents allergies. Conclusion ADR monitoring should be strengthened to improve the rational use of drug and reduce the occurrence of ADR/ADE.

关 键 词：红花注射液 不良反应 事件 

分 类 号：R286[医药卫生—中药学]