人鼻息肉组织白细胞介素-17表达水平及临床意义  

Expression of interleukin-17 in nasal polyps and its clinical significance

作　　者：刘新彦[1] 霍占江 牛敬莲 王晖[1] 单春光[4] 

机构地区：[1]河北北方学院附属第二医院耳鼻咽喉头颈外科,河北省张家口市075100 [2]张家口市第一人民医院耳鼻咽喉科,河北省张家口市075000 [3]石家庄市第五人民医院放射科,050000 [4]河北医科大学第二医院耳鼻咽喉头颈外科,石家庄市050000

出　　处：《中华实用诊断与治疗杂志》2012年第11期1069-1070,1073,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：张家口市科技攻关计划项目(201211240004)

摘　　要：目的探讨人鼻息肉组织标本白细胞介素(interleukin,IL)-17表达水平及临床意义。方法 48例鼻息肉患者术后鼻息肉组织标本(鼻息肉组)与10例正常下鼻甲组织(对照组),采用反转录-聚合酶链反应方法检测2组IL-17mRNA的表达水平。结果鼻息肉组IL-17mRNA光密度值(1.82±0.47)明显高于对照组(0.65±0.08)(P<0.01);鼻息肉组织中IL-17mRNA表达水平在性别、年龄、息肉初发或复发上差异无统计学意义(P>0.05)。结论 IL-17mRNA在鼻息肉组织中呈高表达,与鼻息肉的发生、发展有关。Objective To investigate the expression of interleukin-17 （IL-17） in nasal polyps and its clinical significance. Methods The expression of IL-17 mRNA was detected with reverse transcription PCR technique in 48 cases of nasal polyps and 10 cases of normal inferior turbinate mucosa. Results The expression of IL-17 mRNA was obviously higher in nasal polyps than that in normal inferior turbinate tissue （P^O. 01）. There was no significant difference in the expression of IL-17 mRNA between males and females, different ages, or primary nasal polyps and recurrent nasal polyps （P〉0.05）. Conclusion IL-17 mRNA in human nasal polyps is highly expressed, which is correlated with the development and progress of nasal polyps.

关 键 词：鼻息肉 白细胞介素-17 MRNA 反转录PCR 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]