饮酒对心肌梗死患者冠状动脉侧支循环及血清VEGF水平的影响  

Effects of alcohol intake on coronary collateral circulation and serum level of VEGF in myocardial infarction patients

作　　者：朱烨[1] 孙永乐[1] 苑海涛[1] 张兴华[1] 张玉英[1] 唐元升[1] 

机构地区：[1]山东大学附属省立医院心内科,济南250021

出　　处：《山东大学学报（医学版）》2012年第11期71-74,共4页Journal of Shandong University:Health Sciences

基　　金：山东省优秀中青年科学家科研奖励基金(2007BS03043)

摘　　要：目的探讨不同乙醇摄入量的心肌梗死患者冠状动脉侧支循环水平及血清中血管内皮生长因子(VEGF)水平的变化。方法收集经冠状动脉造影证实至少存在一支主要血管闭塞的冠心病患者103例,对患者侧支循环水平进行Rentrop分级;采用问卷调查收集患者的饮酒量、吸烟、高血压、糖尿病、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)等冠心病危险因素;并根据患者不同饮酒量分为非饮酒组、少量饮酒组(每日乙醇摄入量≤40 g)和大量饮酒组(每日乙醇摄入量>60 g);收集患者动脉血,采用ELISA法检测血清VEGF水平。结果少量饮酒组侧支循环水平高于非饮酒组(P<0.05)和大量饮酒组(P<0.01);少量饮酒组血清VEGF水平(148.32±60.80)pg/mL明显高于非饮酒组(113.53±61.82)pg/mL(P<0.05),而大量饮酒组与少量饮酒组血清VEGF水平无显著性差异(P>0.05)。结论少量饮酒有利于心肌梗死患者冠状动脉侧支循环的建立,可能与血中VEGF高表达有关。Objective To investigate the effects of different amount of alcohol intake on coronary collateral circulation and serum levels of vascular endothelial growth factor（VEGF）in patients with myocardial infarction.Methods 103 cases with at least one major coronary vessel occlusion confirmed by the coronary angiography were collected,and their coronary collateral circulations were classified with the Rentrop scoring system.Patients＇daily alcohol intake and other risk factors of coronary artery disease were collected with the questionnaire survey method.Patients were divided into three groups according to the amount of alcohol intake： the non-drinking group,the light-drinking group（≤40 g per day） and the heavy-drinking group（60 g per day）.Serum levels of VEGF were detected with ELISA.Results Coronary collateral circulations in the light-drinking group were better than those of the non-drinking group（P0.05） and the heavy-drinking group（P0.01）;the serum level of VEGF in the light-drinking group was significantly higher than that of the non-drinking group（148.32±60.80 vs 113.53±61.82）pg/mL（P0.05）,while there was no significant difference in serum levels of VEGF between the light-drinking group and the heavy-drinking group（P0.05）.Conclusion Light alcohol intake may benefit the collateral circulation formation in patients with myocardial infarction,which may be associated with the overexpression of VEGF.

关 键 词：心肌梗死 乙醇 摄入量 侧支循环 血管内皮生长因子 

分 类 号：R541.4[医药卫生—心血管疾病]