吸入伊洛前列素治疗肺动脉高压危象四例  

Aerosolized iloprost therapy for pulmonary hypertensive crisis in 4 patients with idiopathic pulmonary arterial hypertension

作　　者：邓可武[1] 周玉杰[2] 徐希奇[3] 吴明营[1] 王国宏[1] 边红[1] 陈波[1] 王春波[1] 

机构地区：[1]首都医科大学附属北京同仁医院心血管中心,100730 [2]首都医科大学附属北京安贞医院心内科 [3]航空总医院心内科

出　　处：《中华心血管病杂志》2012年第10期854-857,共4页Chinese Journal of Cardiology

摘　　要：目的观察吸入伊洛前列素治疗肺动脉高压危象的疗效和安全性。方法本研究人选4例特发性肺动脉高压患者，发生危象时在基础治疗同时，吸入伊洛前列素10μg／次，每次吸入约10—15min，每2小时1次，每天8次。观察吸入前后体动脉压、心率和超声心动图各项指标的变化以及患者的不适反应。结果4例肺动脉高压危象患者吸入伊洛前列素后肺动脉压明显下降，血氧饱和度明显改善。雾化吸入治疗后有2例患者出现恶心、呕吐、腹泻及干咳等不适，其中1例因出现严重呕吐及腹泻而停止治疗。结论吸入伊洛前列素可以显著降低肺动脉高压危象患者肺动脉压力，改善血氧饱和度。Objective To summary the efficacy and safety of aerosolized iloprost in patients with pulmonary hypertensive crisis. Methods On the basis of conventional therapy, aerosolized iloprost （ 10 μg per time for 10 - 15 min in 2 hours interval, 8 times per day） was administered to four patients with idiopathic pulmonary arterial hypertension and pulmonary hypertensive crisis. Blood pressure, heart rate, systemic artery oxygen saturation, systolic pulmonary arterial pressure （ sPAP ） measured by echocardiography and the adverse events were analyzed. Results After aerosolized iloprost therapy, sPAP was significantly decreased and systemic artery oxygen saturation was improved. Adverse events （ nausea, vomiting, diarrhea, dry cough） were observed in two patients, and the iloprost use was stopped in one patient due to severe vomiting and diarrhea. Conclusion Aerosolized iloprost could significantly reduce the sPAP and improve the systemic artery oxygen saturation in patients with pulmonary hypertension crisis.

关 键 词：高血压 肺性 急诊处理 伊洛前列素 

分 类 号：R544.16[医药卫生—心血管疾病]