羟基磷灰石涂层髋关节假体的研究与应用  

Research and application of hydroxyapatite coated hip prosthesis

作　　者：凌中华[1] 赵建宁[2] 

机构地区：[1]南京大学医学院,江苏省南京市210093 [2]解放军南京军区南京总医院骨科,江苏省南京市210002

出　　处：《中国组织工程研究》2012年第39期7322-7326,共5页Chinese Journal of Tissue Engineering Research

基　　金：国家自然基金青年科学基金项目(81000792)~~

摘　　要：背景:目前含有羟基磷灰石涂层的生物学髋关节假体已广泛应用于临床。目的:复习相关文献,对羟基磷灰石涂层髋关节假体的生物学特性及临床应用效果进行综述。方法:应用计算机检索1988/2011PubMed数据库有关羟基磷灰石涂层髋关节假体生物学特性及临床应用效果的文章,检索词为"hydroxyapatite,hip arthroplasty,hip prosthesis",排除发表时间早、重复及类似研究,纳入29篇文献进一步分析。结果与结论:羟基磷灰石是一种具有良好生物相容性及生物活性的磷酸钙盐,通过处理,它可在金属表面形成薄层,这种处理方法可极大促进紧压配合假体的骨整合,能为假体提供骨性固定,直到骨长入到假体的多孔表面内。羟基磷灰石涂层的非骨水泥假体在置入早期即可促进骨长入,允许早期负重,具有良好的机械固定和长久的生物固定作用,且远期并发症如无菌性松动、假体周围骨溶解、假体下沉的发病率并不高于无羟基磷灰石涂层的髋关节假体。但目前在羟基磷灰石涂层的厚度、羟基磷灰石颗粒的大小、羟基磷灰石材料的结晶度等方面尚无统一意见,需要进一步的研究和探讨。BACKGROUND： Nowadays, biological hip prosthesis coated by hydroxyapatite has been widely used in clinical treatment. OBJECTIVE： To review relevant literatures and to summarize the biological characteristics and clinical application of hydroxyapatite coated hip prosthesis. METHODS： PubMed database were retrieved by computer for articles published from 1988 to 2011 that related to the biological characteristics and clinical application of hydroxyapatite coated hip prosthesis. The key words were ＂hydroxyapatite, hip arthroplasty, hip prosthesis＂. Articles published earlier, repetitive and similar studies were excluded and 29 literatures were included to review. RESULTS AND CONCLUSION： Hydroxyapatite is a kind of calcium phosphate that has excellent biocompatibility and bioactivity. By deal with the surface, it can form a thin layer on the metal surface, this approach can greatly improve the osseointegration of pressed prosthesis, it can make the prosthesis bony fixed until the bone growth into the porous surface of the prosthesis. The hydroxyaptite coated uncemented hip prosthesis can promote bone growth in early implant stage and permit early weight-bearing, leading to a stable and reliable mechanical and biologic fixation. The incidence of long-term complications such as aseptic loosening, periprosthetic osteolysis and prosthesis subsidence is not higher than those of non-hydroxyaptite coated hip prosthesis. However, there is no consensus in the thickness, particle size, crystallinity of the hydroxyaptite coating material, so the further research and discussion are required.

关 键 词：羟基磷灰石 髋关节置换 生物型 髋关节假体 临床预后 

分 类 号：R318[医药卫生—生物医学工程]