椎间盘退行性变的相关生物分子因素  

Intervertebral disc degeneration related molecular biological factors

作　　者：周旭[1] 贺石生[1] 

机构地区：[1]上海同济大学附属第十人民医院骨科,上海市200072

出　　处：《中国组织工程研究》2012年第39期7375-7379,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:随着年龄的增长,椎体过度活动和超负荷承载使椎体加快出现老化,并在外力的作用下,继发病理性改变,以致椎间盘纤维环破裂,椎间盘内的髓核突出,引起腰腿痛和神经功能障碍。目的:总结椎间盘退行性变的相关生物分子因素的研究进展,并展望其发展趋势。方法:应用计算机检索PubMed数据库;中国知网数据库;万方数据库;维普数据库2000-02/2012-01有关椎间盘退行性变的相关生物分子因素的文献。检索文献包括研究原著及综述,排除重复性研究。结果与结论:共保留32篇文献归纳总结。椎间盘退变是由多种相关因素在长期条件下相互作用而引起的,是一系列脊柱退行性病变的前提和慢性病理过程的基础。椎间盘髓核细胞不仅是残留脊索细胞,而且对于整个椎间盘功能的维持起到重要作用。对髓核细胞在RNA、DNA及蛋白水平相关生物分子因素的研究,为延缓及治疗以及将来扭转和修复椎间盘退行性变提供了可能。BACKGROUND： With the age, excessive activity and overload capacity may accelerate ageing of the vertebral body, and under the action of external force and the secondary pathological changes, the annulus of the intervertebral disc rupture and intervertebral disc nucleus pulposus highlight appeared which led to the low back pain and neural dysfunction. OBJECTIVE： To sum up the research advancement of intervertebral disc degeneration related molecular biological factors and the trend of its development. METHODS： A computer-based search was performed on the PubMed database, CNKI database, Wanfang database and Vip database from February 2000 to January 2012 for the articles about the intervertebral disc degeneration related molecular biological factors. The searched literatures included original articles and reviews, and repetitive studies were excluded. RESULTS AND CONCLUSION： Totally 32 articles were concluded to summarize. Intervertebral disc degeneration is caused by a variety of relevant factors interact under long-term conditions; it is the premise of the series spinal degenerative disease and the basis of chronic disease pathological process. Disc nucleus pulposus cells are not only the residual notochord cells, but also play an important role in maintaining the whole disc function. The study of nucleus pulposus cells in RNA, DNA and protein level related molecular biological factors, provides the possibility of delay and treatment, as well as the future torsion and repair of the intervertebral disc degeneration.

关 键 词：椎间盘退行性变 髓核细胞 衰老 凋亡 损伤修复 

分 类 号：R318[医药卫生—生物医学工程]