肾移植后急性排斥反应及免疫抑制剂的应用  

Acute rejection after renal transplantation and application of immunosuppressive agents

作　　者：容松[1] 

机构地区：[1]遵义医学院器官移植实验室,贵州省遵义市563003

出　　处：《中国组织工程研究》2012年第40期7564-7571,共8页Chinese Journal of Tissue Engineering Research

摘　　要：背景:肾移植后急性排斥反应在临床较为常见,免疫抑制剂的出现促进和推动了肾移植质量的提高,免疫抑制剂的合理应用对肾移植患者至关重要,成为影响患者生存率的重要因素。目的:对肾移植后急性排斥反应和免疫抑制剂研究文献进行多层次分析。方法:以电子检索方式对Web of Science数据库2002至2011年收录肾移植后急性排斥反应和免疫抑制剂研究的文献进行分析,采用检索词为"肾移植;急性排斥反应;免疫抑制剂"。对肾移植后排斥反应进行分类,了解肾移植后免疫抑制剂的种类,分析各种免疫抑制剂的特点。结果与结论:Web of Science数据库2002至2011年收录肾移植后急性排斥反应和免疫抑制剂研究的文献共6105篇,文献数量总体呈现出逐步上升的发展状态,《移植学会会报》杂志是发表肾移植后急性排斥反应和免疫抑制剂研究文献较多的期刊。美国在此类研究中发表文献最多,其次为德国。收录文献按被引频次由高到低排序前10位中,有4篇来源于《新英格兰医学》杂志。中国在过去10年间被收录文章总量排在第9名,共发表238篇相关文献,中国的国家自然科学基金资助文献有17篇。BACKGROUND： Acute rejection after renal transplantation is common in clinic, and the immunosuppressive agents can promote and facilitate the improvement of the quality of the renal transplantation, while the reasonable application of immunosuppressive agents is important for the patients with renal transplantation and has become the important factors that affecting the survival rate of patients. OBJECTIVE： To multi-level analyze the literatures on the acute rejection after renal transplantation and the immunosuppressive agents. METHODS： A computer-based search was performed on Web of Science database for the literatures on the acute rejection after renal transplantation and the immunosuppressive agents from 202 to 2011, the key words were ＂renal transplantation, acute rejection, immunosuppressive agents＂. The acute rejection after renal transplantation was classified to study the types of the immunosuppressive agents after renal transplantation and to analyze the characteristics of various immunosuppressive agents. RESULTS AND CONCLUSION： A total of 6 105 literatures on the acute rejection after renal transplantation and the immunosuppressive agents between 2002 and 2011 were screened out from the Web of Science database, and the number of the literature is in an increasing trend. Transplantation Proceedings journal mainly publishes the research on the acute rejection after renal transplantation and the immunosuppressive agents. And the majority of related studies are from the United States, followed by Germany. Among the top 10 literatures arranged according to the cite frequency from high to low, four literatures from The New England Journal of Medicine. In the past 10 years, the number of the included literatures in China is the No. 9, and a total of 238 literatures have been published, among the literatures, there are 17 literatures are supported by the National Natural Science Foundation.

关 键 词：肾移植 排斥反应 免疫抑制剂 环孢素A 他克莫司 雷帕霉素 硫唑嘌呤 泼尼松 吗替麦考酚酯 霉酚酸脂 

分 类 号：R318[医药卫生—生物医学工程]