大疱性类天疱疮患者血清总IgE变化规律及与病情的相关性  

Serum IgE Levels in Patients with Bullous Pemphigoid and Its Correlation with the Activity of the Disease

作　　者：刘冰[1] 左亚刚[1] 李军[1] 

机构地区：[1]中国医学科学院 北京协和医学院 北京协和医院皮肤科,北京100730

出　　处：《协和医学杂志》2012年第4期398-401,共4页Medical Journal of Peking Union Medical College Hospital

基　　金：国家自然科学基金(81071301);教育部新世纪优秀人才项目(NCET-10-0964)

摘　　要：目的探讨大疱性类天疱疮(bullous pemphigoid,BP)患者血清中总IgE变化规律以及与BP病情的相关性。方法收集北京协和医院皮肤科住院及门诊就诊的有完整临床资料的BP患者59例,对其血清总IgE在治疗前后的变化规律进行总结,并对血清总IgE与皮质类固醇激素应用最大剂量、嗜酸性粒细胞总数及间接免疫荧光滴度间的相关性进行分析。结果 59例BP患者中,53例(89.83%)血清总IgE升高,治疗后患者病情好转后IgE下降,但多不能恢复到正常水平。BP患者总IgE水平与激素应用的最大剂量、嗜酸性粒细胞数量、间接免疫荧光滴度均无相关性(P>0.05)。结论 BP患者血清中总IgE水平明显升高,但BP病情好转后IgE不能恢复正常,IgE水平与BP病情严重程度无关。Objective To investigate serum total IgE level in bullous pemphigoid （BP） patients and its correlation with the activity of disease. Methods A total of 59 BP patients admitted to our department were enrolled in the study. Their clinical data were analyzed. The change of serum total IgE level before and after treatment was observed. The correlations between the total IgE level and the maximum dose of steroid during hospital stay, the number of eosinophils, and indirect immunofluorescence （IIF） titer were analyzed. Results Of these 59 patients, 53 （89.83 % ） had elevated serum IgE level. After the disease was controlled, IgE decreased but did not return to normal level. High IgE level lasted for several months or years. The serum IgE level in these BP patients was not correlated with the maximum dose of steroid, number of eosinophils, or IIF titer （ all P 〉 0.05 ）. Conclusions Serum IgE remarkably increases in BP patients, and can not return to the normal thresholds even after the disease is controlled. However, it has no correlation with the severity of BP.

关 键 词：大疱性类天疱疮 IGE 嗜酸性粒细胞 皮质类固醇 间接免疫荧光 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]