电子垃圾拆解区多氯联苯暴露对新生儿生长发育的影响  

Association between Polychlorinated Biphenyls and Development of Neonates from an E-waste Recycling Area

作　　者：陆绍琦[1] 徐锡金[1] 刘俊晓[1] 邱少汕[1] 李斌[1] 张浴玲[1] 霍霞[1] 

机构地区：[1]汕头大学医学院分析细胞学实验室,广东汕头515041

出　　处：《汕头大学医学院学报》2012年第3期135-137,共3页Journal of Shantou University Medical College

基　　金：国家自然科学基金资助项目(30972513)

摘　　要：目的:探讨电子垃圾拆解区多氯联苯(PCBs)的宫内暴露水平及其对胎儿生长发育的影响。方法:气相色谱-质谱联用仪检测贵屿组及濠江组262名新生儿脐带血中7种(CB-28、52、101、138、153、180、209)PCBs同系物浓度,并进行相关因素问卷调查。结果:贵屿组脐带血样本总PCB浓度中位数(76.1 ng/g lipid)显著高于对照组(33.2ng/g lipid)(P<0.01);7种同系物的中位数水平均高于对照组;脐带血中CB-52、153、180及总PCB水平与新生儿出生体质量呈负相关;脐带血中CB-28、101、138、153、180、209及总PCB水平与胎龄呈正相关。结论:贵屿地区新生儿脐带血中的PCBs仍处于较高水平;宫内暴露PCBs可能会影响胎儿的生长发育。Objective： To investigate the influence of PCBs in utero exposure on birth weight and gestafional age. Methods： The umbilical cord blood samples of 262 neonates from Guiyu and Haojiang were collected. PCBs were detected by gas chromatograph-mass spectrometer. Questionnaire was carried out among subjects. Results ： The median of total PCB eoneentration was significant higher in Guiyu （76.1 ng/g lipid ） than control（ 33.2 ng/g lipid ） （ P 〈 0. 01 ）. The median of individual congener concentration was significantly increased in Guiyu compared with Haojiang. CB-52, 153, 180 and total PCB were negatively associated with birth weight. CB-28, 101, 138, 153, 180, 209 and total PCB were posi- tively correlated with gestational age. Conclusion： The concentration of PCBs in umbilical cord blood is still at high level in Guiyu. PCBs in utero exposure may influence the growth and development of the fetus.

关 键 词：电子垃圾 新生儿 多氯联苯 生长发育 

分 类 号：R114[医药卫生—卫生毒理学]