血清中新型癌症生物标记物——miRNA  

A New Cancer Biomarkers in Serum——miRNA

作　　者：李艳[1] 丁伟[2] 

机构地区：[1]杭州师范大学生命与环境科学学院,浙江杭州310036 [2]杭州师范大学理学院,浙江杭州310036

出　　处：《宁夏农林科技》2012年第10期150-152,共3页Journal of Ningxia Agriculture and Forestry Science and Technology

摘　　要：MicroRNA(miRNA)是一类长度约22 nt的非编码单链RNA,广泛存在于动物、植物中,具有基因表达调控的功能。研究表明,miRNA的异常表达与人类的各种癌症相关,且miRNA可作为肿瘤抑制基因或癌基因存在。当前许多研究集中在生理学或病理学过程miRNA表达的研究,血清中miRNA可作为检测各类癌症与疾病的潜在生物标记物用于病人外周血癌症的早期检测与癌症复发的检测。血清miRNA的差异表达对癌症的研究具有较大的前景。MicroRNA（miRNA） is non-coding,single-stranded RNAs of 22 nt and constitute a novel class of gene regulators that is found in both plants and animals.Recent evidences have shown that miRNA aberrant expression correlate with various human cancers and indicate that miRNA can function as tumour suppressors and oncogenes.While many studies have focused on miRNA expression in physiological and pathological processes,variables related to miRNA for new serum biomarkers have simultaneously emerged.Now miRNA has been applied to early detection of cancer and monitoring of cancer recovery by using detection of peripheral blood.Several studies have demonstrated that serum miRNA could serve as potential biomarkers for the detection of various cancers and other diseases.

关 键 词：MIRNA 癌症 血清 生物标记物 

分 类 号：Q52[生物学—生物化学]