白藜芦醇对快速老化鼠肝脏抗氧化能力的影响  

Effect of resveratrol on antioxidant abilities of liver in senescence accelerated mice

作　　者：刘贵珊[1] 杨博[2] 范艳丽[1] 张泽生[3] 贺伟[3] 

机构地区：[1]宁夏大学农学院,宁夏银川750021 [2]宁夏大学新华学院,宁夏银川750021 [3]天津科技大学食品工程与生物技术学院,天津300457

出　　处：《农业科学研究》2012年第3期23-25,共3页Journal of Agricultural Sciences

基　　金：高等学校博士学科点专项科研基金(20101208110001)

摘　　要：分析白藜芦醇对快速老化鼠(SAMP/8)肝脏抗氧化能力的影响.将4月龄雄性SAMP/8鼠随机分为模型组和白藜芦醇低、中、高剂量组,4月龄正常老化SAMR/1鼠为正常对照组.对照组及模型组用生理盐水灌胃,白藜芦醇治疗组给予25、50和100mg/kg白藜芦醇灌胃.连续给药8周,测定各组小鼠肝组织超氧化物歧化酶(SOD)、丙二醛(MDA)的含量,以HE染色进行肝组织形态学观察.结果表明:白藜芦醇各剂量组能提高SAMP/8鼠肝组织SOD活性(P<0.01),降低MDA含量(P<0.01),且能改善肝组织形态结构,尤以高剂量组效果显著.因此,白藜芦醇能显著提高SAMP/8鼠肝组织的抗氧化能力,具有一定的延缓衰老作用.To observe the effect of resveratrol on antioxidant abilities of liver in senescence accelerated mice. Four-month old SAMP/8 mice were divided into four groups randomly： The model group, resveratrol low- dose, moderate-dose and high-dose groups, and four-month old SAMR/1 mice were in normal control group. The normal control group and model group were given normal saline by garage, Res-treated mice were administered Res by garage at the daily doses of 25 mg/kg, 50 mg/kg and 100 mg/kg respectively. After medication for 8 weeks,superoxide dismutase （SOD）, malondialdehyde （MDA） in the liver of mice were determined, histological changes in mice liver tissue were observed after HE stain. Resveratrol could significantly increase activities of SOD （P〈 0.01 ）, decrease the content of MDA （P% 0.01 ） in liver tissue and ameliorate histological structure of liver tissue. Resveratrol could significantly improve antioxidant abilities of liver in SAMP/8 mice and have anti-aging effect.

关 键 词：白藜芦醇 快速老化鼠 抗氧化 

分 类 号：R284[医药卫生—中药学]