住院2型糖尿病患者发生低血糖的危险因素分析  

The analysis of risk factors for hypoglycemia in hospitalized patients with type-2 diabetes

作　　者：王波[1] 汤智慧[1] 熊娜[1,2] 黄清杰[1,3] 马亮[1] 巴建明[4] 窦京涛[4] 母义明[4] 

机构地区：[1]解放军总医院药品保障中心临床药学室,北京100853 [2]解放军261医院药械科,北京100094 [3]甘肃省中医院药学部,甘肃兰州730050 [4]解放军总医院内分泌科,北京100853

出　　处：《中国药物应用与监测》2012年第5期252-255,共4页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:探讨2型糖尿病患者发生低血糖的相关危险因素,为临床糖尿病治疗过程中血糖安全达标、有效规避低血糖提供参考。方法:选择2010年4月–2011年12月于我院内分泌科住院的640例2型糖尿病患者,其中发生过明确低血糖的患者132例(低血糖组),未发生低血糖的患者508例(无低血糖组)。对两组患者的临床数据进行单因素χ2检验或Fisher精确概率分析和多因素logistic回归分析。结果:患者年龄、内生肌酐清除率(Ccr)、BMI、糖尿病病程以及住院天数是低血糖发生的独立危险因素(P<0.05)。结论:2型糖尿病患者较长的糖尿病病程、肾功能不全、年龄小、BMI过低均会增加低血糖发生风险,而由于住院期间的强化治疗,住院时间过长会增加低血糖的暴露。因此,对于具有上述高危因素的人群应积极预防低血糖。Objective： To explore the risk factors for hypoglycemia in hospitalized type-2 diabetic patients, provide the reference for reaching the standard of blood sugar and avoiding hypoglycemia. Methods： A total of 640 type-2 diabetic patients were collected in inpatient department of our hospital from April, 2010 to December, 2011. There were 132 subjects identified as hypoglycemia and 508 subjects as no hypoglycemia. The clinical data of two groups were compared and logistic regression analysis was performed to reveal the risk factors for hypoglycemia. Results： Longer duration of diabetes, longer hospital days, lower body mass index were more common in patients with hypoglycemia as compared to those without them. With logistic regression analysis, age, endogenous creatinine clearance rate, body mass index, the duration of diabetes and hospital days were independent risk factors of hypoglycemia （P 〈 0.05）. Conclusion： In hospitalized type-2 diabetic patients, longer duration of diabetes, longer hospital days, lower body mass index and renal dysfunction increase the hypoglycemia. On the other hand, longer hospital days may make the exposure of hypoglycemia. So clinical practitioners should adopt measure to balance the hyperglycemia therapy and hypoglycemia.

关 键 词：2型糖尿病 低血糖 危险因素 临床药师 

分 类 号：R587.1[医药卫生—内分泌]