TP-ELISA法检测心脏病患者易产生假阳性的原因分析  

Reason analysis of false-positive which is easy to produce detected by TP-ELISA method from patients with heart disease

作　　者：李亚[1] 

机构地区：[1]河南省商丘市第一人民医院输血科,河南商丘476100

出　　处：《中国当代医药》2012年第30期96-97,共2页China Modern Medicine

摘　　要：目的探讨应用梅毒酶联免疫吸附试验(TP-ELISA)检测心脏病患者易产生假阳性结果的原因。方法采用TP-ELISA法分别检测本院1350例心脏病患者和2780例非心脏病患者的血清,结果阳性者再用TPPA法进行确诊,并对两组患者的梅毒特异性抗体假阳性率进行对比分析。结果 TP-ELISA法检测心脏病患者假阳性率明显高于非心脏病患者组,两组差异有统计学意义(P<0.01)。结论脂质异常和年龄因素是造成TP-ELISA法检测梅毒抗体易发生假阳性的原因。Objective To explore the reason of false-positive which is easy to produce detected by treponema pallidum enzyme-linked immuno sorbent assay （TP-ELISA） method from patients with heart disease.Methods The serum from 1 350 cases of patients with heart disease and 2 780 cases of patients without heart disease were respectively detected by TP-ELISA.The results with positive were definitely diagnosed by TPPA method.The false positives of syphilis specificity antibody in two groups of patients were compared and analyzed.Results The false positives rate for patients with heart disease detected by TP-ELISA method was higher than the group of patients without heart disease with significant difference （P 0.01）.Conclusion Lipids abnormal and age factor are the causes of false-positive for syphilis antibody which is easy to produce detected by TP-ELISA method.

关 键 词：TP-ELISA 心脏病 梅毒抗体 假阳性 

分 类 号：R446.61[医药卫生—诊断学]