IL-6基因多态性与乙型肝炎慢性化的相关性  

IL-6 Genetic Polymorphisms influences the chronicity outcomes of HBV infection

作　　者：高宝霞[1] 浦江[2] 张国顺[3] 高华[4] 冯福民[5] 

机构地区：[1]河北联合大学附属开滦医院感染性疾病科,063000 [2]唐山市中医院CT室 [3]河北联合大学附属医院消化内科 [4]唐山市人民医院检验科 [5]河北联合大学公共卫生学院

出　　处：《肝脏》2012年第10期700-703,共4页Chinese Hepatology

基　　金：河北省卫生厅医学科学研究重点课题(20100128);唐山市科技局科学技术研究且慢发展指导计划项目(121302019a)

摘　　要：目的探讨汉族成人IL-6基因多态现象与乙型肝炎慢性化的关系。方法收集118例慢性乙型肝炎(CHB)患者和61例急性乙型肝炎(AHB)患者外周血,提取基因组DNA;采用聚合酶链反应-限制性片断长度多态性(PCR-RFLP)分析方法进行IL-6-572C/G和-597G/A基因分型。结果 CHB组IL-6-572G等位基因频率显著高于AHB组(χ2=8.627,P=0.003)。与CC基因型相比,CG和GG基因型携带者发生慢性化的危险性升高(ORCG=2.024,95%CI:1.009～4.065;ORGG=3.367,95%CI:1.169～9.709)。结论 IL-6-572基因位点多态性与乙型肝炎慢性化有关,携带-572GG基因型的乙型肝炎患者易发生慢性化。Objective To investigate the association between the gene polymorphisms of IL-6 and the chronicity of HBV infection among Chinese adults of the Han nationality. Methods Blood sample of 118 cases of chronic hepatitis 13 （CHB） 61 cases of acute hepatitis B （AHB） were collected. IL-6 -572C/G and -597G/A were typed by PCR-RFLP; T text, Chi-squre and multivariate unconditional Logistic analysis were conducted with SPSS （11.5） window software. Results A significant correlation was found between CHB infection and IL-6 -572 C/G, while no gene mutations was found in the -597 G/A. The frequency of IL-6 -572 C allele in CHB patients was higher than that of AHB patients （X2 = 8. 627, P = 0. 003）. IL-6 -572GG genotype occurred more frequently in CHB patients than that in AHB patients, with crude ORcG = 2. 024, 95 % CI： 1. 009-4. 06; ORGG = 3. 367, 95% CI： 1. 169-9. 709. After drinking, HBV DNA, the status of HBeAg and blood- types had been adjusted, the result of multivariate Logistic regression analysis also showed that the -572GG genotype was significantly associated with CHB. Conclusion SNPs in IL-6 -572 gene have significantly affected on the chronicity of hepatitis B infection. The GG genotype of IL-6 -572 is the high risk of chronicity of HBV infection.

关 键 词：乙型肝炎 慢性化 多态性 基因 IL-6 

分 类 号：R512.62[医药卫生—内科学]