卵磷脂脂质体对高脂血症兔动脉成形术后狭窄的影响  

The Effects of Lecithin Phospholipid Liposomes on Arterial Narrowing after Balloon Angioplasty in Rabbits

作　　者：和渝斌[1] 王人彭[2] 曾小林 徐宁生[2] 王克勤[3] 

机构地区：[1]北京军区总医院心血管病研究所,北京100700 [2]北京医科大学心血管病研究所,北京100083 [3]中国协和医科大学生物化学教研室,北京100010

出　　处：《中国动脉硬化杂志》2000年第2期115-117,共3页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金资助课题

摘　　要：为了解口服卵磷脂脂质体对动脉粥样硬化兔动脉成形术后再狭窄的影响 ,将 5 0只新西兰兔随机分为五组。观察组、高脂组、假手术组进食高脂饲料 ,手术组和对照组进食普通饲料。观察组、手术组及高脂组分别行左侧髂动脉成形术 ,观察组在动脉成形术后给予卵磷脂脂质体溶液干预。结果发现 ,与高脂组比较 ,观察组左侧髂动脉内径显著增大 ,血管壁增厚 ,胆固醇含量明显减少 ,主动脉粥样硬化面积明显减小 ,高密度脂蛋白胆固醇浓度明显增加 ,极低密度脂蛋白胆固醇、低密度脂蛋白胆固醇、总胆固醇及甘油三酯浓度明显降低 (P均 <0 .0 5 )。结果提示 。Aim To evaluate the effects of lecithin phospholipid liposomes on arterial narrowing after balloon angioplasty in the atherosclerosis rabbits. Methods 50 New Zealand rabbits were divided into observation group (high lipid food plus lecithin phospholipid liposomes), operation group ( no lipid food ), nonoperation group (high lipid food only ) , high lipid group (high lipid food only) and control group ( no lipid food ). The rabbits of the observation group, operation group and high lipid group were underwent balloon angioplasty in the left common iliac artery. The observation group was given lecithin phospholipid liposomes liquids. Results It had indicated the rabbits left iliac arterial lumen diameter was larger, its wall was thicker and its cholesterol concentration was smaller in the observation group than that of the high lipid group (P< 0.05). Aortic arterial plaque area in the observation group was less than that of the high lipid group (P<0.001). In the observation group, higher HDLC, lower VLDLC, LDLC, TC and TG concentration can be observed than that of the high lipid group (P<0.05). Conclusion Lecithin phospholipid liposomes could effectively reduce arterial narrowing in the atherosclerosis rabbits.

关 键 词：卵磷脂脂质体 动脉粥样硬化 脂蛋白 高脂血症 

分 类 号：R589.202[医药卫生—内分泌]