雌二醇抑制大鼠动脉损伤后内膜增生  

Effect of Estradiol on Inhibition Neointimal Proliferation after Rat Carotid Artery Injury

作　　者：赵智深[1] 黄从新[1] 江洪[1] 杨波[1] 李庚山[1] 王滕 王晶[1] 

机构地区：[1]湖北医科大学附属第一医院心内科,湖北省武汉市430060

出　　处：《中国动脉硬化杂志》2000年第2期121-123,共3页Chinese Journal of Arteriosclerosis

基　　金：湖北省九五攻关项目!(项目批准号962P1101)

摘　　要：为探讨雌二醇对去势大鼠颈总动脉球囊损伤后内膜增生的影响 ,选择 8- 10周S -D大鼠 ,雌性、雄性各 2 1只 ,各分三组 :非去势对照组 (n =7)、去势对照组 (n =7)和实验组 (n =7,去势 +雌二醇 )。腹腔注射雌二醇三天后 ,以 2 .0F经皮腔内冠状动脉成形术球囊损伤左颈总动脉。动脉损伤两周后处死大鼠 ,测量内膜面积、内膜面积与中膜面积的比值。结果发现 ,雄性实验组内膜面积 ( 0 .0 72± 0 .0 2 0mm2 )、内膜面积与中膜面积的比值 ( 0 .5 33±0 .0 37)均显著小于非去势对照组 ( 0 .110± 0 .0 18mm2 和 0 .740± 0 .0 5 1,P均 <0 .0 1)和去势对照组 ( 0 .0 98± 0 .0 14mm2 和 0 .70 1± 0 .0 40 ,P均 <0 .0 5 )。雌性实验组内膜面积 ( 0 .0 6 1± 0 .0 15mm2 )、内膜面积与中膜面积比值 ( 0 .5 2 5±0 .0 30 )均显著小于去势对照组 ( 0 .10 1± 0 .0 18mm2 和 0 .710± 0 .0 31,P均 <0 .0 1) ,但与非去势对照组 ( 0 .0 78± 0 .0 12mm2 和 0 .6 19± 0 .0 41)差异不显著 (P均 >0 .0 5 )。Aim To investigate the effect of estradiol on inhibition of neointimal proliferation after rat carotid artery balloon injury. Methods Eight-ten week-old S-D rats were divided into intact control group (n=7), gonadectomized control group (n=7) and estradiol (n=7,gonadectomization)group in each sex. Left carotid artery was not injured with 2.0F PTCA balloon until estradiol had been injected for three days. Rats were killed after injury two weeks later. Neointimal areas, ratios of intimal areas and media areas were measured with computer. Results Neointimal areas and ratios of inttimal areas and media areas in male in estradiol group were significantly less than those in intact control group (all P<0.01), and in gonadectomized control group (all P<0.05). Those in female ,in estradiol group were less than those in godectomized control group evidently (all P<0.01),were also similar to those in intact control group (all P>0.05). Conclusion Estradiol inhibited neointimal proliferation after the gonadectomized rat carotid artery balloon injury.

关 键 词：雌二醇 内膜增殖 内皮损伤 平滑肌 颈动脉 

分 类 号：R543.5[医药卫生—心血管疾病]