温针腰神经根受压大鼠前列腺素E_2的水平  

Warm needling regulates the prostaglandin E_2 in a rat model of lumbar nerve root compression

作　　者：谢艳艳[1] 吴耀持[1] 

机构地区：[1]上海交通大学附属第六人民医院针推伤科,上海市200233

出　　处：《中国组织工程研究》2012年第37期6951-6955,共5页Chinese Journal of Tissue Engineering Research

基　　金：上海市科学技术委员会资助课题(04419723):从细胞因子调控探讨温和灸对大鼠腰神经根受压模型的作用机制~~

摘　　要：背景:研究表明温针对降低大鼠腰神经根受压模型中前列腺素E2表达有重要意义。目的:探讨温针对大鼠腰神经根受压模型中前列腺素E2的调节作用,并与针刺和美洛昔康作对比。方法:60只SD大鼠随机等分为正常组、模型组、美洛昔康组、针刺组和温针组,后4组通过放置硅胶片建立大鼠腰神经根受压模型。美洛昔康组、针刺组、温针组大鼠分别在造模后予以3.75mg/kg美洛昔康灌胃、针刺和温针腰L5夹脊穴治疗14d。结果与结论:美洛昔康、针刺和温针都可以降低大鼠受压腰神经根组织中前列腺素E2的水平(P<0.01),温针较美洛昔康和针刺能更明显地降低前列腺素E2水平(P<0.01),提示温针可以有效地降低大鼠腰神经根受压模型中的前列腺素E2。BACKGROUND：Studies have demonstrated that warm needling exerts an important role in prostaglandin E2 expression in a rat model of lumbar nerve root compression. OBJECTIVE：To explore the regulating effects of warm-needling on prostaglandin E2 expression of rat models of lumbar nerve root compression, and to compare the efficacy of acupuncture and meloxicam. METHODS：Sixty Sprague-Dawley rats were randomly divided into five groups. They were normal group, model group, meloxicam group, acupuncture group and warm needling group. Rats in the latter four groups were prepared for rat models of lumbar nerve root compression by placing silicone films. The rats in the normal group were not modeled and had no therapy. The rats in the model group were modeled but not treated. After modeling, the rats in the meloxicam, acupuncture and warm needling groups were subjected to intragastric administration of 3.75 mg/kg meloxicam, acupuncture and warm needling for 14 days, respectively. RESULTS AND CONCLUSION：Meloxicam, acupuncture, warm-needling all could reduce the content of prostaglandin E2 in rats with lumbar nerve root compression （P 0.01）. Compared to meloxicam and acupuncture, warm needling could better reduce the content of prostaglandin E2 （P 0.01）. The findings indicate that warm needling can effectively reduce the content of prostaglandin E2 in rats with lumbar nerve root compression.

关 键 词：温针 腰神经根受压模型 前列腺素E2 针刺 美洛昔康 大鼠 组织构建 

分 类 号：R318[医药卫生—生物医学工程]