未成熟心肌体外循环动物模型的建立  

The method of setting up immature myocardium cardiopulmonary bypass(CPB) animal model

作　　者：熊荣生 刘邕波 邓盛 杨娜 陈华夏 

机构地区：[1]南溪山医院心胸外科,广西桂林541002

出　　处：《局解手术学杂志》2012年第6期642-643,共2页Journal of Regional Anatomy and Operative Surgery

基　　金：广西壮族自治区卫生厅立项课题(Z2006141)

摘　　要：目的探讨建立未成熟心肌体外循环动物模型的方法。方法选用小于8周的同种健康本地幼犬20只,将20只幼犬随机分为浅低温体外循环不停跳组(实验组)及冷晶体液间断灌注心脏停跳组(对照组)2个组。2种动物模型建立后,观测转流过程中血液动力学和血气分析指标的变化。结果 2组实验动物模型体外循环转流过程中,血液动力学平稳和血气分析指标正常。结论幼犬体外循环动物模型的建立能满足对未成熟心肌的研究要求。Objective To explore the method of setting up immature myocardium cardiopulmonary bypass （CPB） animal model. Meth- ods 20 healthy local young dogs （ 〈 8 weeks） were randomly divided into 2 groups： one is beating heart with mild hypothermia cardiopul- monary bypass group （experimental group）, the other one is cardiac arrest with crystalloid intermit perfusion group （control group）. The changes of homodynamic index and blood-gas analysis index were observed in the process of bypass. Results Animal models of the two groups were all of stable blood dynamics and normal blood-gas analysis index in the process of bypass. Conclusion The establishment of young dog CPB animal models can meet the requirements of studying immature myocardium.

关 键 词：心脏 体外循环 动物模型 

分 类 号：R654.1[医药卫生—外科学] R-332[医药卫生—临床医学]