镧修饰羧基化氧石墨烯的抑菌性能  

The antimicrobial properties of carboxylated graphene oxide decorated with La particles

作　　者：王晓丹[1,2] 周宁琳[1,2,3] 汪炜燕[1,2] 汤毅达[1,2] 章峻[1,2,3] 沈健[1,2,3] 

机构地区：[1]南京师范大学江苏省生物医药功能材料工程研究中心,江苏南京210097 [2]南京师范大学江苏省生物功能材料重点实验室,江苏南京210097 [3]南京大学江苏省表面与界面工程技术研究中心,江苏南京210093

出　　处：《新型炭材料》2012年第5期385-392,共8页New Carbon Materials

基　　金：江苏省自然科学基金(BK2009408);国家自然科学基金(20874047);江苏高校优势学科建设工程资助项目(PAPD);江苏省产学研前瞻性联合研究项目(BY2011109)~~

摘　　要：在氧化石墨烯(GO)的研究和应用中,为充分发挥其优良性质,必须对其进行功能化。笔者将稀土La3+离子接枝到羧基化的GO(GO-COOH)片层上,制备了一种功能化的镧修饰羧基化氧石墨烯(La/GO-COOH)。利用红外光谱、热重分析和透射电镜等手段对合成的La/GO-COOH进行了表征,结果表明,La3+已通过化学和物理作用吸附在GO片层上。通过细菌生长动力学实验评价了La/GO-COOH的抑菌性能,结果表明,La/GO-COOH对大肠杆菌有很好的抑菌效果,当浓度为0.5 mg/mL,抑菌率达96.40%;对金黄色葡萄球菌和铜绿假单胞菌也均有抑菌效果,因此La/GO-COOH是具有抑菌性能的新型GO负载物;与未剥离的镧修饰氧化石墨(La/GTO)相比,由于剥离的GO片层的比表面积大,其吸附La3+离子的量高于氧化石墨(GTO),故La/GO-COOH复合物的抑菌性远优于La/GTO。Graphene oxide （GO） was functionalized by acetyl chloride to form carboxylated graphene oxide （GO-COOH）. GO-COOH decorated with La particles with diameters between 0.2 and 1 μm was prepared by the sonication of a LaC13 aqueous solution with GO-COOH. The La-decorated GO-COOH was characterized by PT-IR, TGA and TEM, and its antibacterial properties were characterized by bacteria growth kinetics. Results showed that the La3~ ions were coordinated on edges and corrugated parts of the GO-COOH by physical and chemical bonding. The La-decorated GO-COOH had a good inhibitory efficiency of 96.4% on the E. coli when its concentration was 0.5 mg/mL. It also had inhibitory effects on S. aureus and the P. Aeruginosa. The better antibacterial effect of the La-decorated GO-COOH than the corresponding La-decorated GTO was ascribed to the higher amount of La particles incorporated on the GO-COOH.

关 键 词：氧化石墨烯 氧化石墨 三氯化镧 细菌生长动力学 

分 类 号：O613.71[理学—无机化学]