听力正常的耳鸣患者的耳蜗外毛细胞功能研究  

The study of cochlear outer hair cells function in normally hearing patients with tinnitus

作　　者：刁明芳[1] 孙建军[1] 田芳洁[1] 贾仲红[1] 刘阳[1] 陈东兰[1] 

机构地区：[1]海军总医院全军耳鼻咽喉科中心,北京100048

出　　处：《中国中西医结合耳鼻咽喉科杂志》2012年第5期334-336,共3页Chinese Journal of Otorhinolaryngology in Integrative Medicine

基　　金：海军总医院人才库资助项目

摘　　要：目的用畸变产物耳声发射(distortion product evoked oto-acoustic emissions,DPOAE)检测听力正常耳鸣患者的耳蜗外毛细胞(outer hair cell,OHC)功能。方法选取门诊50例听力正常(250～8000Hz)伴有耳鸣的患者,对照组选取年龄性别匹配的听力正常无耳鸣的志愿者。比较两组受试者的DPOAE幅值。结果与对照组相比,耳鸣组DPOAE幅值降低,在高频(4～8kHz)的幅值差异有显著性(P<0.05)。结论 DPOAE幅值下降与听力正常患者的耳鸣产生有关,耳蜗OHC功能受损可能是耳鸣的来源。Objective To compare cochlear outer hair cells functionin normally hearing patients with and without tinnitus based on distortion product otoacoustic emission（DPOAE）, Methods Fifty tinnitus patients with normal hearing in the frequency range between 250 to 8000 Hz were selected as a study group. The control group consisted of 50 otologically normal subjects who have normal hearing threshold levels without tinnitus and were selected to match the study group by age and gender. DPOAE-grams of tinnitus group were compared with theose of control group. Results Tinnitus ears exhibited relatively decrease amplitudes of DPOAE when compared with the group of healthy ears .Statistically significant 0a〈 0.05） decrease mean values of DPOAE amplitudes were observed at a frequency of 4-8kHz. Conclusions There is an association between tinnitus and reduced distortion product otoacoustic emission amplitudes. The reduced cochlear outer hair cells function may be the source oftinnitus.

关 键 词：耳鸣 听力正常 外毛细胞功能 耳蜗 

分 类 号：R764.45[医药卫生—耳鼻咽喉科]