基于体素的多系统萎缩梯度回波横向弛豫率R2＊分析  

Voxel-based Relaxometry of Transverse Relaxation Rate with Gradient Echo R2 ＊ in Patients with Multiple System Atrophy

作　　者：侯波[1] 有慧[1] 王含[2] 赵彦萍[3] 姜波[1] 孙宏毅[1] 崔丽英[2] 冯逢[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院放射科,北京100730 [2]中国医学科学院北京协和医学院北京协和医院神经科,北京100730 [3]中国中医科学院广安门医院放射科,北京100053

出　　处：《中国医学科学院学报》2012年第5期450-454,共5页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(30670608)~~

摘　　要：目的对震颤麻痹型多系统萎缩(MSA-P)患者与正常人的梯度回波横向弛豫率R2*进行基于体素的分析,探索其全脑R2*情况的差异。方法入组27例MSA-P患者及24例健康志愿者,分别行全脑结构成像及多回波梯度回波成像,然后对其R2*图进行基于体素的分析。结果与对照组相比,MSA-P组R2*值减低累及双侧脑干、小脑半球、岛叶、颞叶、尾状核及胼胝体,差异具有统计学意义(P<0.005)。结论 R2*可以反映MSA-P患者脑内变化,梯度回波序列在提高灵敏度的同时,也带来了较强的伪影,干扰了其检出效能。Objective To explore the transverse relaxation rate with gradient echo R2 ＊ changes in patients with Parkinsonian variant of multiple system atrophy （MSA-P） with a voxel-based analysis of R2 ＊ map. Methods Whole brain structural images and multi-echo T2 ＊ weighted image were acquired in 27 pa- tients with probable MSA-P and 24 healthy individuals. R2 ＊ maps of the MSA-P were compared with the con- trols by voxel-hased methods. Result Compared with the controls, MSA-P patients showed significant R2 ＊ decrease bilaterally in brain stem, cerebellar hemispheres, insular lobe, temporal lobes, caudate nucleus, and corpus callosum （ P 〈 0. 005 ）. Conclusions R2 ＊ can reveal the significant brain involvements of MSA-P. The introduction of gradient echo may increase the sensitivity, although the susceptible artifact may interfere the detection efficiency of R2 ＊

关 键 词：多系统萎缩 磁共振成像 弛豫率测量 

分 类 号：R445.2[医药卫生—影像医学与核医学]