红景天属植物及其原花青素成分对酪氨酸酶及Aβ42聚集的抑制活性  

Inhibitory effects of Rhodiola plants and their oligomeric proanthocyanidins on tyrosinase and Aβ42 aggregation

作　　者：陈博凡[1] 杨雁芳[1] 张英涛[1] 

机构地区：[1]北京大学药学院,北京100191

出　　处：《药学学报》2012年第11期1440-1446,共7页Acta Pharmaceutica Sinica

基　　金：北京市自然科学基金资助项目(7112090)

摘　　要：酪氨酸酶(tyrosinase)是与老年人皮肤色素异常沉积密切相关的关键酶,而β淀粉样肽Aβ42的自我聚集则被认为是导致阿尔茨海默病的关键病因。本研究对红景天属植物20个样品的酪氨酸酶及Aβ42聚集抑制活性进行了系统分析与活性成分的分离,结果证明了该属植物普遍含有的原花青素成分(oligomeric proanthocyanidins,OPCs)可能为抑制酪氨酸酶及Aβ42聚集的主要活性成分,而该属植物的代表性成分红景天苷则未表现出明显的抑制作用。Tyrosinase is a key enzyme related to skin pigmentation disorders of elderly people, while self-aggregation of the amyloid-fl peptide, Aft42, has been considered as a key event in the pathogenesis of Alzheimer＇s disease （AD）. The present study was undertaken to investigate the inhibitory effects of 20 samples from Rhodiola species on tyrosinase and Aβ42 aggregation, and to isolate their corresponding bioactive components. The results demonstrated that the oligomeric proanthocyanidins （OPCs） commonly found in Rhodiola species were the major bioactive components corresponding to their anti-tyrosinase and anti-Aβ42 aggregation bioactivities. Salidroside, a representative compound of Rhodiola plants, proved not to be active in the present studies.

关 键 词：红景天属 原花青素 阿尔茨海默病 酪氨酸酶 AΒ42 

分 类 号：R285[医药卫生—中药学]