妊娠期糖尿病患者脂代谢异常对新生儿出生体质量的影响  

Effects of Abnormal Lipid Metabolism in Patients with Gestational Diabetes Mellitus on Body Mass of Newborn

作　　者：匡德凤[1] 华绍芳[1] 韩玉环[1] 

机构地区：[1]天津医科大学第二医院产科,300211

出　　处：《天津医药》2012年第11期1128-1130,共3页Tianjin Medical Journal

摘　　要：目的:研究妊娠期糖尿病(GDM)患者脂代谢异常对新生儿出生体质量的影响,为合理管理妊娠期糖尿病孕妇提供临床参考。方法:106例妊娠女性分为妊娠期糖尿病(GDM组,n=50)组、妊娠期糖耐量受损(GIGT组,n=24)组及糖耐量正常(NGT组,n=32)。比较3组孕妇血脂水平、孕期体质量增加及相关围产资料。结果:GDM组总胆固醇(TC)及三酰甘油(TG)水平均高于GIGT和NGT组,差异有统计学意义(P<0.05)。3组孕妇分娩前体质量差异有统计意义(P<0.01),且GDM组明显高于其他2组。GDM组新生儿出生体质量、孕妇术中羊水粪染及新生儿转入重症监护病房(NICU)的概率高于其他2组,差异有统计学意义(P<0.05);GDM组孕妇空腹血糖、TG水平及孕妇孕期体质量增加与新生儿出生体质量间存在正相关(r分别为0.528、0.632、0.585,P<0.05)。结论:在控制血糖的基础上,积极控制血脂水平,可减少巨大儿的发生及围产期并发症,保障母婴安全。Objective： To study the influences of abnormal lipid metabolism in patients with gestational diabetes mellitus （GDM） on neonatal birth weight and provide clinical references for reasonable management of GDM. Methods： A total of 106 pregnant women were divided into GDM group （n=50）, gestational impaired glucose tolerance （GIGT） group （n= 24） and normal glucose tolerance （NGT） group （n=32）. The values of blood lipid levels, weight gain during pregnancy and perinatal data were recorded and compared in three groups. Results： The levels of total cholesterol （TC） and triacylglycerol （TG） were significantly higher in GDM group than those of GIGT group and NGT group （P 〈 0.05）. The average weight of pregnant women was significantly different between three groups, and which was higher in GDM group than that of other two groups （P 〈 0.01）. The neonatal birth weight, meconium-stained and the probability that newborns were transferred to the neonatal intensive care unit （NICU） were significantly higher in GDM group than those of other two groups （P 〈 0.05）. The levels of blood glucose, TG and increased body weight of pregnancy were positively correlated with the neonatal body weight （r=0.528, 0.632 and 0.585,P 〈 0.05）. Conclusion： The perinatal complications can be reduced by control blood glucose and blood lipid levels, ensuring the safe motherhood.

关 键 词：糖尿病 妊娠 脂代谢障碍 婴儿 新生 出生体质量 

分 类 号：R722[医药卫生—儿科]