二氧化硫衍生物对雌性大鼠性激素的影响  

Effects of sulfur dioxide derivatives on sex hormones in female rats

作　　者：薄芳芳[1] 何玉洁[1] 成要平[1] 

机构地区：[1]山西医科大学第一临床医院妇产科,山西太原030001

出　　处：《中国妇幼保健》2012年第31期4973-4976,共4页Maternal and Child Health Care of China

摘　　要：目的:探讨二氧化硫衍生物对大鼠性激素的影响。方法:将30只雌性大鼠随机分为对照组、低剂量组、高剂量组,连续染毒14天,观察卵泡刺激素(FSH)、血清雌二醇(E2)、黄体生成素(LH)激素水平及对卵巢组织结构的影响。结果:低剂量、高剂量组与对照组比较大鼠血清中FSH水平均明显升高(P<0.05),高剂量组大鼠血清中LH与对照组比较升高明显(P<0.05),低剂量、高剂量组大鼠血清中E2水平明显降低(P<0.05)。高剂量组大鼠卵巢组织的病理改变表现为始基卵泡和初级卵泡增多,而次级卵泡和成熟卵泡较少见,且闭锁卵泡增多。结论:二氧化硫衍生物可引起雌性大鼠性轴功能紊乱及卵巢组织学改变。Objective： To explore the effects of sulfur dioxide derivatives on sex hormones in female rats. Methods： A total of 30 female rats were randomly divided into control group, low - dose group, and high - dose group, then they were exposed to sulfur dioxide derivatives consecutively for 14 days; the levels of follicle stimulating hormone （FSH）, serum estradiol, luteinizing hormone （LH）, and the effects on ovarian tissue and structure were observed. Results： Compared with control group, the levels of serum FSH in low - dose group and high - dose group increased significantly （P 〈 O. 05 ） ; the serum level of LH in high - dose group was statistically significantly higher than that in control group （ P 〈 0.05 ） ; the serum levels of estradiol in low - dose group and high - dose group decreased significantly （ P 〈 0.05 ） ; the pathological manifestations of ovarian tissue in rats in high - dose group included increases of primordial follicles and primary follicles, but secondary follicles and mature follicles were few, and the number of atretic follicles increased. Conclusion： Sulfur dioxide derivatives can induce the dysfunction of gonadal axis and the changes of ovarian tissue in female rats.

关 键 词：二氧化硫 性激素 卵巢 

分 类 号：R58[医药卫生—内分泌]