葡聚糖-肼屈嗪前药的合成与表征  

Synthesis and characterization of dextran-hydralazine macromolecule prodrug

作　　者：高瑞雪[1] 张娟[1] 张亚洲[1] 邢晓虎[1] 

机构地区：[1]西北大学应用化学研究所,陕西西安710069

出　　处：《西北大学学报（自然科学版）》2012年第5期763-765,共3页Journal of Northwest University（Natural Science Edition）

基　　金：陕西省自然科学基金资助项目(2011JM2114);陕西省教育厅科研计划基金资助项目(09JK791)

摘　　要：目的研究葡聚糖-肼屈嗪大分子前药的合成方法。方法用丁二酸酐做连接基试剂与葡聚糖反应,生成中间体葡聚糖丁二酸酯,将中间体的端羧基与肼屈嗪的氨基反应。结果合成了葡聚糖-肼屈嗪,并用红外光谱,DSC和紫外光谱进行分析表征。合成的前药产率大于82%。肼屈嗪在前药中的质量分数为8.3%。结论该方法实验操作简单,反应条件较温和,产率高,具有较好的研究价值。Aim To study a method for synthesis of dextran-hydralazine macromolecule prodrug. Methods Dextran was modified by succinic anhydride, then connected with hydralazine. Results Dextran-hydralazine prodrug was synthesized. The product was characterized by IR, DSC and UV. The productivity of this prodrug is 82%, and the content of hydralazine in the prodrug is 8.3%. Conclusion The prodrug preparation method is simple, appli- cable with mild condition, and has high productivity, which owns good prospect of application.

关 键 词：葡聚糖 肼屈嗪 合成 

分 类 号：O621.3[理学—有机化学]