Iniparib的合成  

Synthesis of Iniparib

作　　者：纪文华[1] 高乾善[1] 李瑞梅 

机构地区：[1]山东省分析测试中心,山东济南250014 [2]美国VRL实验室,马里兰州20705

出　　处：《中国医药工业杂志》2012年第11期888-889,共2页Chinese Journal of Pharmaceuticals

摘　　要：对氨基苯甲酸经酰化、硝化、水解、重氮化及碘代反应制得4-碘-3-硝基苯甲酸,再依次与氯化亚砜、氨水反应生成聚腺苷二磷酸核糖聚合酶抑制剂iniparib,总收率约35%。Iniparib, a poly-ADP-ribose polymerase inhibitor, was synthesized from 4-aminobenzoic acid by acetylation, nitration, hydrolysis, diazotization and iodination to give 4-iodo-3-nitrobenzoic acid, which was subjected to reaction with SOC12 and ammonium hydroxide successively with an overall yield of about 35 %,

关 键 词：iniparib 聚腺苷二磷酸核糖聚合酶抑制剂 抗肿瘤药 合成 

分 类 号：R979.19[医药卫生—药品]