盐酸非那嗪奈含量及有关物质的HPLC法测定  

Determination of Fenazinel Dihydrochloride and Its Related Substances by HPLC

作　　者：周一萌[1] 周斌[1] 

机构地区：[1]中国医药工业研究总院上海医药工业研究院,上海200040

出　　处：《中国医药工业杂志》2012年第11期943-945,共3页Chinese Journal of Pharmaceuticals

摘　　要：建立了高效液相色谱法测定盐酸非那嗪奈的含量及有关物质。使用LiChroCART RP-18色谱柱,流动相为0.3%三乙胺溶液(用磷酸调至pH7.0)-甲醇(37︰63),检测波长246nm。盐酸非那嗪奈与有关物质的分离度良好。线性范围为0.01～2 mg/ml,平均回收率为100.1%,RSD为0.13%。An HPLC method was established for the determination of fenazinel dihydrochloride and its related substances. A LiChroCART RP-18 column was used with the mobile phase of 0.3% triethylamine （adjusted to pH 7.0 with phosphoric acid）-methanol （37 ： 63） at the detection wavelength of 246 nm. Fenazinel dihydrochloride and its related substances were separated successfully. The calibration curve was linear in the concentration range of 0.01 - 2 mg/ml. The average recovery was 100.1%, with RSD of 0.13 %.

关 键 词：盐酸非那嗪奈 有关物质 高效液相色谱 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.72[化学工程—制药化工]