聚乳酸-羟基乙酸纳米粒表面功能化修饰及其应用  

Surface Modification and Application of Poly(lactic-co-glycolic acid) Nanoparticles

作　　者：毛立丽[1] 刘洁[1] 杨亚妮[1] 卞玮[1] 何军[1] 

机构地区：[1]中国医药工业研究总院药物制剂国家工程研究中心,上海200437

出　　处：《中国医药工业杂志》2012年第11期954-958,共5页Chinese Journal of Pharmaceuticals

摘　　要：聚乳酸-羟基乙酸(PLGA)纳米粒表面特性是影响其体内分布的重要因素,经表面修饰的PLGA纳米粒已广泛应用于靶向给药系统研究。本文综述了PLGA纳米粒表面修饰的方法,包括共价交联、静电作用及疏水作用力等,概述了表面修饰纳米粒在非特异性生物黏附和生物渗透、特异性靶向、延长体循环时间及稳定生物活性分子方面的应用。The surface property of poly（lactic-co-glycolic acid） （PLGA） nanoparticles has an important effect on the in vivo distribution. The surface-modified PLGA nanoparticles have been wildly used in the research of active targeting drug delivery system. The methods of surface modification including covalent cross-link, electrostatic interaction and hydrophobic interaction are reviewed in this paper, and the applications of surface-modified nanoparticles to non-specific bioadhesion and penetration, specific targeting, extending circulating time and maintaining the stability of biologically active molecules are briefly introduced.

关 键 词：聚乳酸-羟基乙酸 纳米粒 表面修饰 应用 综述 

分 类 号：R944.9[医药卫生—药剂学]