前列腺素E_1联合贝那普利治疗早期特发性膜性肾病疗效观察  

Therapeutic efficacy of prostaglandin E_1 combined with Benazepril in the treatment of early idiopathic membranous nephropathy

作　　者：韩久怀[1] 刘伟[1] 张璟[1] 施杰[1] 端靓靓[1] 苏安生[1] 

机构地区：[1]安徽省安庆市立医院肾内科,安徽安庆246003

出　　处：《中国医药导报》2012年第29期92-93,98,共3页China Medical Herald

摘　　要：目的探讨前列腺素E1(PGE1)联合贝那普利对早期特发性膜性肾病的临床疗效。方法选择早期特发性膜性肾病患者52例,采用前瞻、随机、对照研究,分为对照组、PGE1组、贝那普利组、PGE1+贝那普利组。对照组仅给予限制蛋白饮食,血脂升高者给予降脂等一般治疗;PGE1组在对照组基础上给予PGE1 100μg加5%葡萄糖100 mL静滴,每日1次,共用4周;贝那普利组在对照组地基础上给予贝那普利10 mg/d,如无副作用及低血压,增加剂量至20 mg/d;PGE1+贝那普利组在PGE1组的基础上合用贝那普利10～20 mg/d,每日1次,共用4周。结果与治疗前比较,除对照组外,PGE1组、贝那普利组与PGE1+贝那普利组24 h尿白蛋白量均有下降(P<0.01);与其他组比较,PGE1+贝那普利组作用更显著(P<0.05)。结论 PGE1联合贝那普利对早期特发性膜性肾病有较好的治疗效果。Objective To investigate the therapeutic efficacy of prostaglandin E 1（PGE 1） combined with Benazepril in the treatment of early idiopathic membranous nephropathy.Methods 52 cases of early-stage idiopathic membranous nephropathy patients were enrolled in a prospective randomized controlled study.Patients were assigned to control group,PGE 1 group,Benazepril group and PGE 1 combined with Benazepril group.The control group only received restricted protein diet and patients with elevated blood lipids were given general treatment of lipid-lowering;In addition to that,PGE 1 group were given intravenous infusion of 20 μg PGE 1 in 100 mL 5% glucose once a day,for 4 weeks;in addition to treatment given in the control group,patients in the Benazepril group were given Benazepril 10 mg/d and the dose was raised to 20 mg/d in the absence of side effects and low blood pressure;patients in the PGE 1 combined with Benazepril group were given Benazepril 10-20 mg/d for 4 weeks in addition to treatment given in the PGE 1 group.Results Except for control group,after treatment 24 h urinary albumin volume decreased in PGE 1 group,Benazepril group and PGE 1 combined with Benalapril group（P0.01）;compared with other groups,PGE 1 combined with Benazepril group showed more significant effect（P0.05）.Conclusion PGE 1 combined with Benazepril shows promising therapeutic efficacy in the treatment of early idiopathic membranous nephropathy.

关 键 词：早期 特发性膜性肾病 前列腺素E1 贝那普利 

分 类 号：R692.3[医药卫生—泌尿科学]