Controllable precipitation of naproxen micro-particles with different morphologies  

作　　者：Peng Cheng KangkangJin Jing Cheng Fang Yang Zhigang Shen Jianfeng Chen Lixiong Wen 

机构地区：[1]State Key Laboratory of Organic-lnorganic Composites,Beijing University of Chemical Technology,Beijing 100029,China [2]Research Center of the Ministry of Education for High Gravity Engineering&Technology,Beijing University of Chemical Technology,Beijing 100029,China

出　　处：《Particuology》2012年第5期634-643,共10页颗粒学报（英文版）

基　　金：support provided by National Natural Science Foundation of China(Nos.21121064 and 20990224);National Science and Technology Ministry(No.2008BAE64B02)

摘　　要：A simple precipitation method was proposed to prepare naproxen micro-particles with different controllable morphologies, using capillary video microscopy to study the precipitation process. Different particle shapes were obtained including spherical, platelet-like, stick-like, needle-like, and butterfly-like, all in the micro-size range. It was found that the sizes and morphologies of the formed naproxen particles were sensitive to the nature and concentration of the added surfactant, and depended significantly on processing conditions such as temperature, stirring speed, and initial drug concentration. In addition, pre- cipitation with different surfactant types and concentrations would not affect the crystal microstructure of the formed nanroxen oarticles.A simple precipitation method was proposed to prepare naproxen micro-particles with different controllable morphologies, using capillary video microscopy to study the precipitation process. Different particle shapes were obtained including spherical, platelet-like, stick-like, needle-like, and butterfly-like, all in the micro-size range. It was found that the sizes and morphologies of the formed naproxen particles were sensitive to the nature and concentration of the added surfactant, and depended significantly on processing conditions such as temperature, stirring speed, and initial drug concentration. In addition, pre- cipitation with different surfactant types and concentrations would not affect the crystal microstructure of the formed nanroxen oarticles.

关 键 词：PrecipitationCrystal growthNaproxenSurfactants 

分 类 号：TQ463.4[化学工程—制药化工] O413.1[理学—理论物理]