高敏C反应蛋白与外周血管疾病的关系  

The Relationship Between High-sensitivity C-Reactive Protein and Peripheral Artery Disease

作　　者：张茵[1] 孙羽[1] 卞瑾[1] 宋颖[1] 吴亚杰[1] 陈伊[1] 冯新星[1] 王怡璐[2] 高硕[2] 王继征[2] 邹玉宝[1] 宋雷[1] 惠汝太 孙凯[2] 

机构地区：[1]中国医学科学院,北京协和医学院,国家心血管病中心,阜外心血管病医院心内科,北京市100037 [2]中国医学科学院,北京协和医学院,国家心血管病中心,阜外心血管病医院心血管疾病国家重点实验室,北京市100037

出　　处：《中国分子心脏病学杂志》2012年第5期257-259,共3页Molecular Cardiology of China

基　　金：国家重大基础项目2010CB732601

摘　　要：目的探讨中国人群中高敏C-反应蛋白(Hs-CRP)与周围血管疾病(Peripheral Artery Disease,PAD)的关系。方法入选2004 年-2010年在我院就诊的 837例疑似冠心病患者,其中男553例,女284例,平均年龄59.31±9.85岁. 检测ABI,以 ABI≤0.9 作为诊断外周血管病的标准,检测患者血清 Hs-CRP 水平,调查其一般生活习惯,既往史。结果 68名患者被诊断为外周血管病,患病率为 8.1%。血清 Hs-CRP 水平与 ABI 值的高低显著相关,随着血清 Hs-CRP 水平的增高,ABI 值逐步降低,两者呈线性负相关关系。同时,PAD 患者中,血清 Hs-CRP 水平较高者占的比例高于非PAD患者。血清Hs-CRP水平最高一组发生PAD的风险是血清Hs-CRP水平最低一组的2.78倍(95%CI:1.21-6.41)。结论中国人群中血清 Hs-CRP 水平与 PAD 显著相关,是 PAD 的预测因子。Objective To determine the relation between high-sensitivity C-reactive protein and peripheral artery disease. Methods In our study, 837 patients with suspected CAD were investigated. Characteristics of studied subjects including demographics, familial history, past medical history and atherosclerotic risk factors such as high-sensitivity C-reactive protein were investigated. ABI was measured in all studied patients. ABI≤0.9 was considered as peripheral vessel disease and ABI〉0.9 was considered as normal. Results There are 68 patients who diagnosed as PAD, the prevalence of PAD were 8.1%. The serum Hs-CRP was significantly inversely associated with ABI, the proportion of high Hs-CRP was significantly higher in PAD patients than in controls . The elevated Hs-CRP had a 1.78 fold increased risk of PAD in forth quartiles than in first quartiles. Conclusioon Our findings of this study indicated that serum Hs-CRP level is related with ABI and the high Hs-CRP is an independent risk factor for PAD in Chinese.

关 键 词：高敏C-反应蛋白 外周血管疾病 踝臂指数 

分 类 号：R543[医药卫生—心血管疾病]