KLF2的抗动脉粥样硬化的研究进展  

Research Progress of KLF2 Anti-atherosclerosis

作　　者：贾燕珺[1] 李建军[1] 

机构地区：[1]中国医学科学院阜外心血管病医院,中国医学科学院,北京协和医学院,国家心血管病中心,阜外医院,心血管疾病国家重点实验室

出　　处：《中国分子心脏病学杂志》2012年第5期303-307,共5页Molecular Cardiology of China

摘　　要：KLF2是近年新被发现的转录因子。因其在肺高表达,故又被称为LKLF2。其主要机能是稳定胸腺T细胞,调控T细胞的归巢和成熟,并参与生物体细胞分化和血管形成过程,在生物体的天然免疫及组织器官形成方面发挥重要的保护作用。近年研究报道了,KLF2具有抗炎症、保护内皮、抗凝血防止血栓形成及抗氧化机能,参与抗动脉粥样硬化防御调控。随着研究的不断深入,其将可能成为心血管疾病防治的重要防御标志因子。It was been found that KLF2 is a new transcription factors in recent years. Because of it is high expression in the lungs, so it is also called LKLF2. The function of KLF2 is stable T cell, and to regulated T cell homing and T cell mature in thymus. KLF2 involved in the differentiation of cells, vascular formation. And it give play to an important role in the response of natural immunity and the formation organism tissues. In recent years, it was been reported roles of KLF2 that it could anti-inflammation, anti-injury, anti-thrombosis and anti-oxidant function, and KLF2 involved in the prevention of atherosclerosis. With the development of research, KLF2 may become an important biomarker to sign cardiovascular disease prevention and treatment.

关 键 词：KLF2 抗动脉粥样硬化 抗炎症 抗内膜损伤 抗氧化 

分 类 号：R543.5[医药卫生—心血管疾病]