安非他酮与帕罗西汀治疗抑郁症的治疗依从性对照研究  

A control study of bupropion and paroxetine in the treatment compliance of patients with depression

作　　者：严伟良[1] 

机构地区：[1]浙江省绍兴市第七人民医院心身疾病科,浙江绍兴312000

出　　处：《中国临床药理学杂志》2012年第10期731-733,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价安非他酮与帕罗西汀治疗抑郁症的药物疗效。方法将60例符合CCMD-3抑郁症诊断标准的患者随机分为2组,分别给予安非他酮和帕罗西汀,治疗后1,2,4,6周后评价疗效和观察不良反应。结果 2组改善抑郁症状的起效时间相似,治疗6周末汉密顿抑郁量表(HAMD)评分分值下降无统计学意义,但安非他酮组药物不良反应较帕罗西汀组少。结论安非他酮治疗抑郁症患者更可以提高病人的治疗依从性。Objective To investigate the efficacy of bupropion and par- oxetine in the treatment of patients with depression. Methods Sixty patients met CCMD -3 depression diagnostic criteria were randomly di- vided into 2 groups treated with bupropion and paroxetine respective- ly. The efficacy and adverse reactions were evaluated at week 1 s,, 2,d, 4th and 6th after the drug administration. Results The onset times of depres- sive symptoms improvement in two groups were similar. The decline of HAMD scores was not statistically significant between two groups at the end of 6 weeks. But the adverse reactions of bupropion were less than those of paroxetine. Conclusion Bupropion can improve the treatment compliance of depressive patients.

关 键 词：安非他酮 帕罗西汀 抑郁症 

分 类 号：R971.43[医药卫生—药品] R749.41[医药卫生—药学]