杀菌剂嘧菌酯的合成工艺  

The Synthesis Techniques of Fungicide Azoxystrobin

作　　者：于福强[1,2] 牛盾[1] 于春睿[2] 武恩明[2] 叶艳明[2] 薛有仁 王徵[2] 

机构地区：[1]东北大学理学院化学系,沈阳110819 [2]沈阳化工研究院有限公司新农药创制与开发国家重点实验室,沈阳110021

出　　处：《农药》2012年第11期789-791,共3页Agrochemicals

基　　金：国家重点基础研究发展计划(973计划)项目(2012CB724501)

摘　　要：[目的]探索一种新的(E)-2-[2-(6-氯嘧啶-4-基氧基)苯基]-3-甲氧基丙烯酸甲酯和水杨腈通过缩合反应合成嘧菌酯的方法,并优化其合成工艺。[方法]以甲苯为溶剂,通过考察敷酸剂的种类和用量、反应温度和相转移催化剂的用量,确定较优的工艺参数。[结果]在优化的反应条件下,合成收率大于98.5%;甲醇精制1次后,产品含量大于98.0%。[结论]该工艺收率高、操作简便、产品纯度高,适合工业化生产。[Aims] The objective is to explore a new preparation method of azoxystrobin by the condensation reaction of material（E）-methyl 2-（2-（6-chloropyrimidin-4-yloxy）phenyl）-3-methoxyacrylate and 2-hydroxybenzonitrile,and the synthetic process was optimized and improved.[Methods] In order to determinate the optimum parameters,the reaction conditions such as the kinds and the quantity of acid-binding agent,reaction temperature and the quantity of phase transfer catalyst were investigated,with toluene as solvent.[Results] Under the optimal reaction conditions,the synthetic yield was greater than 98.5%,refined by methanol once,product content was up to 98.0%.[Conclusions] This synthetic process has some characteristics,such as high yield,simple operation and high purity,and it＇s suitable for industrial production.

关 键 词：杀菌剂 嘧菌酯 合成 甲苯 

分 类 号：TQ455.4[化学工程—农药化工]