中国人脂联素基因多态性与冠心病相关性研究的Meta分析  

A Meta analysis on the association between adiponectin gene polymorphisms and coronary atherosclerotic heart disease in Chinese population

作　　者：张再伟[1,2] 丁世芳[1] 卢青[1] 赵亚玲[2] 姜娜[1] 谢琳[1] 

机构地区：[1]南方医科大学附属广州军区武汉总医院,武汉430070 [2]西安交通大学医学院

出　　处：《现代预防医学》2012年第21期5532-5535,共4页Modern Preventive Medicine

摘　　要：目的探讨中国人脂联素基因多态性与冠心病的相关性。方法通过计算机检索文献,收集2012年3月以前完成或发表的有关中国人脂联素基因多态性与冠心病相关性研究的病例对照研究,剔除不符合要求的文献,以漏斗图检验入选文献的偏倚,并根据各入选文献结果的同质性检验结果进行Meta分析,计算总OR值。结果共16篇文献符合条件纳入研究。入选文献无明显偏倚。Meta分析显示基因+45T/G和+276G/T多态性与冠心病易感性的OR值分别为0.89(95%CI:0.49～1.14)、1.30(95%CI:0.73～2.31)。结论中国人群脂联素基因多态性与冠心病易感性无相关性。OBJECTIVE To explore the association between single nucleotide polymorphisms of adiponectin gene and coronary atherosclerotic heart disease in Chinese population.METHODS We surveyed case-control studies on the association of adiponectin gene polymorphisms with coronary heart disease in Cochrane Library,Chinese Biomedical Literature Database,Wanfang and China National Knowledge Infrastructure.All articles were strictly evaluated and screened according to inclusion criteria,and meta-analysis was performed for the included studies using RevMan 4.2.2 software.RESULTS 16 case-control studies about polymorphism that were based on our inclusion criterion and available in the literature were reviewed.Results from Meta-analysis demonstrated no significant association between ＋45T /G,＋276G /T polymorphism and coronary disease in the Chinese population,and the combined OR of the allele ＋45T /G,＋276G to susceptibility of the disease was 0.89（95% CI：0.49-1.14）,1.30（95%CI：0.73-2.31） respectively.CONCLUSION The current paper on Meta-analysis demonstrates no significant association between ＋45T /G,＋276G /T single nucleotide polymorphism and the coronary disease in Chinese population.

关 键 词：脂联素 基因多态性 冠心病 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]