妊高征孕妇24h尿蛋白水平与肾脏叶间动脉血流动力学检测的研究  被引量:2

Analysis of the dynamics of IRA blood flow and 24 hour urine protein of PIH pregnant woman

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作  者:回丽妹[1] 

机构地区:[1]河北工程大学附属医院产科,河北邯郸056002

出  处:《现代预防医学》2012年第21期5543-5545,共3页Modern Preventive Medicine

基  金:邯郸市科学技术研究与发展计划项目(1123108078-12)

摘  要:目的研究妊娠高血压综合征(PIH)孕妇肾脏叶间动脉(IRA)的血流动力学及24h尿蛋白水平变化规律,探讨它们在预测围产期结局中的诊断价值及对孕妇肾损害的评估。方法选取2010年11月~2011年9月来河北工程大学检查的妊娠晚期妇女,正常妊娠妇女96例(对照组),妊高征患者110例。应用彩超检测孕妇肾脏叶间动脉的PI、RI及S/D,测量双顶径、股骨长度及超声体重,并结合患者24h尿蛋白水平,应用SPSS16.0软件进行统计分析。结果轻度组与对照组PI、RI及S/D值的比较差异无统计学意义(P﹥0.05);中度组与轻度组RI值的比较差异无统计学意义(P﹥0.05);其他各组间的比较差异均有统计学意义(P﹤0.05);各组之间24h蛋白尿水平比较差异有统计学意义(P﹤0.05);孕妇肾脏叶间动脉RI与24h尿蛋白水平呈正相关(r=0.491,P﹤0.05)。重度组与轻度组及对照组双顶径、股骨长,超声体重的比较差异均有统计学意义(P﹤0.05)。结论妊高征孕妇的肾脏叶间动脉的血流阻力增高,造成相应程度的肾损害。与测定24h尿蛋白水平相结合对肾损害的程度判断更为准确。随血压的升高,胎儿双顶径、股骨长,超声体重逐渐减小,胎儿宫内发育迟缓,预测围产期结局不良。OBJECTIVE To study the law of variation in the dynamics of IRA blood flow and 24 hour urine protein of the PIH pregnant women,in order to explore its value in predicting its outcome and renal impair in perinatal period.METHODS From December 2010-September 2011,in the hospital of Hebei University of Engineering,selected 96 cases of normally junior pregnant women as the control group and 110 PIH patients as the subject group.Checked with color Doppler ultrasound,PI,RI and S /D of IRA,measured the values of BPD,FL and ultrasound indicated body weight.Combined with 24 hour urine protein of PIH patients.Their clinical manifestations and ultrasonographic signs were analyzed by SPSS16.0 Software.RESULTS The comparison between the values of IRA-PI,IRA-RI and IRA-S /D for the group of mild PIH cases and that of the control group had no statistical implications(P﹥0.05).The comparison between the values of IRA-S /D for the group of moderate PIH cases and that of the severe PIH cases had no statistical implications(P ﹥ 0.05).The comparison between the values of other groups did have statistical implications(P﹤0.05).Meanwhile,the comparison of 24 hour urine protein between the values of each other did have statistical implications(P﹤0.05);maternal RI was positively related to 24 hour urine protein(r = 0.491,P﹤0.05).The comparison between the values of BPD,FL,ultrasound indicated body weight for the group of the severe PIH cases and that of the control group,the severe PIH cases and the mild,had statistical implications(P ﹤ 0.05).CONCLUSION The resistance of blood flow of kidney increases,which results in some renal impair.It is more exact to predict renal impair by combining with 24 hour urine protein of PIH patient.The values of BPD,FL,ultrasound indicated body weight progressively decreases as the blood pressure increases,and intrauterine growth retardation appears,which predicts its outcome deteriorating in perinatal period.

关 键 词:妊高征 24h尿蛋白水平 肾脏叶间动脉 血流动力学 

分 类 号:R714.246[医药卫生—妇产科学]

 

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