FIB、T淋巴细胞亚群和CRP在慢性阻塞性肺疾病的表达与相关性研究  

A study on expression and relativity for fibrinogen,T lymphocyte subsets and C-reactive protein in patients with chronic obstructive pulmonary diseases

作　　者：刘艳萍[1] 陈大宇[1] 李宏梅[1] 潘柳吟[1] 

机构地区：[1]广西柳州市人民医院检验科,广西柳州545001

出　　处：《现代预防医学》2012年第21期5662-5663,5666,共3页Modern Preventive Medicine

摘　　要：目的探讨血浆纤维蛋白原(FIB)、T淋巴细胞亚群和C反应蛋白(CRP)在慢性阻塞性肺疾病(COPD)的表达与相关性。方法分别检测50例COPD病人急性加重期、稳定期及50例健康者血浆纤维蛋白原(FIB)、T淋巴细胞亚群(CD3+、CD4+、CD8+)和C反应蛋白(CRP)含量,并行第一秒用力呼气容积占预计值百分比(FEV1%预计值)。结果 COPD病人急性加重期及稳定期血清血浆纤维蛋白原(FIB)、CD4+和C反应蛋白(CRP)含量较健康者组均明显升高,差异有统计学意义(P﹤0.05)。稳定期的血浆纤维蛋白原(FIB)、CD4+和C反应蛋白(CRP)水平较急性加重期均明显下降,差异有统计学意义(P﹤0.05)。血浆纤维蛋白原(FIB)、CD4+和C反应蛋白(CRP)水平与FEV1%呈负相关(P﹤0.01)。结论检测血浆纤维蛋白原(FIB)、T淋巴细胞亚群和C反应蛋白(CRP)对于了解慢性阻塞性肺疾病病情具有重要价值。s：OBJECTIVE To discuss expression and relativity of fibrinogen,T lymphocyte subsets and C-reactive protein in patients with chronic obstructive pulmonary diseases.METHODS The serum CRP,T lymphocyte（CD3 ^＋,CD4^＋,CD8 ^＋） and fibrinogen were detected in COPD patients during acute episode and remission,and healthy subjects,50 persons respectively.FEV1% was detected during the time.RESULTS The CRP,CD4^＋ and fibrinogen levels were higher in the patients,during acute episode and remission,than that in the controls（P﹤ 0.05）.After treatment,the CRP,CD4^＋ and fibrinogen in the patients with acute episode declined（P﹤0.05）.The CRP,CD4^＋ and fibrinogen were negatively correlated with the FEV1%（P﹤ 0.01）.CONCLUSION The determination of serum CRP,T lymphocyte and fibrinogen is of definite significance in assessment of status and therapy of COPD at its acute exacerbation.

关 键 词：慢性阻塞性肺疾病 纤维蛋白原 T淋巴细胞亚群 C反应蛋白 

分 类 号：R563[医药卫生—呼吸系统]